Медицинская библиотека · Acta neurologica Scandinavica · 2005

Specific matrix metalloproteinase expression in focal myositis: an immunopathological study.

Rodolico C, Mazzeo A, Toscano A, Messina S, Aguennouz M, Gaeta M, Messina C, Vita G

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Аннотация

OBJECTIVES

The aim of our study was to investigate immunoexpression of matrix metalloproteinases MMP2, MMP7 and MMP9 in muscle specimens from patients with focal myositis (FM) vs polymyositis (PM) and dermatomyositis.

MATERIALS AND

METHODS

We studied muscle biopsy samples from seven patients affected by FM; samples from five patients each with PM and dermatomyositis were studied as disease controls.

RESULTS

MMP2 immunoreactivity was present in PM and dermatomyositis, MMP7 only in PM, and MMP9 in PM, dermatomyositis and FM.

CONCLUSIONS

Our results confirm that increased MMP9 immunoreactivity in muscle fibres is a common feature of all inflammatory myopathies and suggest that MMP2 and MMP7 cannot be implicated in the inflammatory events of FM.

Для цитирования: Rodolico C, Mazzeo A, Toscano A, Messina S, Aguennouz M, Gaeta M, Messina C, Vita G. Specific matrix metalloproteinase expression in focal myositis: an immunopathological study.. Acta neurologica Scandinavica. 2005. DOI: 10.1111/j.1600-0404.2005.00457.x.

Предметные рубрики MeSH

Adult Aged Biopsy Dermatomyositis Female Humans Male Matrix Metalloproteinase 2 Matrix Metalloproteinase 7 Matrix Metalloproteinase 9 Matrix Metalloproteinases Middle Aged Muscle Fibers, Skeletal Muscle, Skeletal

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