Experimental encephalitozoonosis in the blue fox. Clinical and serological examinations of affected pups.

Two groups of blue fox pups about 1½— 2 and 2½—3 months old, respectively, suffering from experimental encephalitozoonosis, were examined clinically and serologically. Antibodies to Encephalitozoon cuniouli were detected in all pups, the titres varying within the range 10–12,800. In addition to unspecific signs of disease the pups showed various neurological disturbances including ataxia, posterior weakness, lameness and circling behaviour, terminaiting in recumbency, paralysis or convulsions. Reduced sight or blindness was observed occasionally. Some of the pups appeared thirsty. Haematological examinations revealed pronounced leukocytosis without any conspicuous shift within the various groups of leukocytes. Biochemical examinations of serum showed significant elevated values of urea nitrogen, creatinine, and magnesium concentrations, reflecting renal dysfunction. Alanine aminotransferase was found significantly depressed in both groups. Raised levels of total protein were demonstrated due to pronounced hyperglobulinaemia. This finding, together with the common occurrence of generalized polyarteritis nodosa and proliferations of plasma cells in clinically affected pups, is probably a result of autoimmune disturbances initiated directly or indirectly by the protozoan infection.