Gaceta medica de Mexico · 2021

Consensus on hemophilia in Mexico.

Consensus StatementСтатьяНазвание и аннотация: Перевод в очереди

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López-Arroyo José L, Pérez-Zúñiga Juan M, Merino-Pasaye Laura E, Saavedra-González Azucena, Alcivar-Cedeño Luisa María, Álvarez-Vera José Luis, Anaya-Cuellar Irene, Arana-Luna Luara L, Ávila-Castro David, Bates-Martín Ramón A, Cesarman-Maus Gabriela, Chávez-Aguilar Lénica A, Peña-Celaya José A de la, Espitia-Ríos María E, Estrada-Domínguez Patricia, Fermín-Caminero Denisse, Flores-Patricio Willy, Chávez Jaime García, García-Lee María T, González-Pérez Ma Del Carmen, González-Rubio Ma Del Carmen, González-Villareal Ma Guadalupe, Ramírez-Moreno Fabiola, Hernández-Colin Ana K, Hernández-Ruiz Eleazar, Herrera-Olivares Wilfrido, Leyto-Cruz Faustino, Loera-Fragoso Sergio, Martínez-Ríos Annel, Miranda-Madrazo María R, Morales-Hernández Alba, Nava-Villegas Lorena, Orellana-Garibay Juan J, Palma-Moreno Orlando G, Paredes-Lozano Eugenia P, Peña-Alcántara Paula, Pérez-Lozano Uendy, Pichardo-Cepín Yayra M, Reynoso-Pérez Ana Carolina, Rodríguez-Serna Mishel, Rojas-Castillejos Flavio, Romero-Rodelo Hilda, Ruíz-Contreras Josué I, Segura-García Adela, Silva-Vera Karina, Soto-Cisneros Paulina M, Tapia-Enríquez Ana L, Tavera-Rodríguez Martha G, Teomitzi-Sánchez Óscar, Tepepa-Flores Fredy, Valencia-Rivas María D, Valle-Cárdenas Teresa, Varela-Constantino Ana, Javier-Morales Adrián, Martínez-Ramírez Mario A, Tena-Cano Sergio, Terrazas-Marín Ricardo, Vilchis-González Shendel P, Villela-Peña Atenas, Mena-Zepeda Verónica, Ibarra Martha Alvarado

Аннотация

Hemophilia is a hemorrhagic disorder with a sex-linked inherited pattern, characterized by an inability to amplify coagulation due to a deficiency in coagulation factor VIII (hemophilia A or classic) or factor IX (hemophilia B). Sequencing of the genes involved in hemophilia has provided a description and record of the main mutations, as well as a correlation with the various degrees of severity. Hemorrhagic manifestations are related to levels of circulating factor, mainly affecting the musculoskeletal system and specifically the large joints (knees, ankles, and elbows). This document is a review and consensus of the main genetic aspects of hemophilia, from the inheritance pattern to the concept of women carriers, physiopathology and classification of the disorder, the basic and confirmation studies when hemophilia is suspected, the various treatment regimens based on infusion of the deficient coagulation factor as well as innovative factor-free therapies and recommendations for the management of complications associated with treatment (development of inhibitors and/or transfusion-transmitted infections), or secondary to articular hemorrhagic events (hemophilic arthropathy). Finally, relevant reviews of clinical and treatment aspects of hemorrhagic pathology characterized by acquired deficiency of FVIII secondary to neutralized antibodies named acquired hemophilia.

Предметные рубрики MeSH

Algorithms Hemophilia A Mexico

Consensus on hemophilia in Mexico.

Ошибки и ограничения

Аннотация

Предметные рубрики MeSH