Internal medicine (Tokyo, Japan) · 2022
Ulcerative Colitis-associated Spondyloarthritis Successfully Treated with Infliximab in the Absence of Enhanced TNF-α Responses.
Клинический случайСтатьяНазвание и аннотация: Перевод в очереди
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Fujita Shunsuke, Honjo Hajime, Takada Ryutaro, Hara Akane, Masuta Yasuhiro, Otsuka Yasuo, Handa Kohei, Minaga Kosuke, Tsuji Shigeyoshi, Kudo Masatoshi, Watanabe Tomohiro
Аннотация
Although concurrent occurrence of spondyloarthritis (SpA) and ulcerative colitis (UC) is sometimes seen, the profiles of cytokines have been poorly understood in UC-associated SpA. We herein report a case of UC-associated SpA successfully treated with infliximab (IFX). Profiles of cytokines in the serum and colonic mucosa were characterized by an enhanced expression of IL-6 but not tumor necrosis factor (TNF)-α. Successful induction of remission by IFX was associated with the downregulation of IL-6 expression but no significant alteration in TNF-α expression. These findings suggest that some cases of UC-associated SpA might be driven by IL-6, and IFX might be effective in cases lacking enhanced TNF-α responses.