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Войти в исследования Arthritis & rheumatology (Hoboken, N.J.) · 2026
Telomere Length of Peripheral Blood Leukocytes Predicts Disease Severity and Worse Survival in Systemic Sclerosis.
СтатьяНазвание и аннотация: Перевод в очереди
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Yang Monica M, Liu Shuo, Wax Michael, Lee Seoyeon, French Sarah, Wolters Paul J, Boin Francesco
Аннотация
OBJECTIVE: Peripheral blood leukocyte telomere length (PBL-TL) shortening is associated with systemic sclerosis-related interstitial lung disease (SSc-ILD). However, its association with other organ involvement, disease severity, and survival remains unclear. This study aimed to define the relationship of TL with SSc-specific disease manifestations and outcomes.
METHODS: PBL-TL was measured by quantitative polymerase chain reaction in 244 patients with SSc and 314 healthy controls. Multivariate modeling was used to assess the association of PBL-TL with disease severity and event-free survival. Longitudinal changes in PBL-TL were measured in a subset of patients. TL was quantified in SSc skin and lung tissues by telomere fluorescence in situ hybridization.
RESULTS: PBL-TL was significantly shorter in patients with SSc than healthy controls. Shortened PBL-TL was associated with presence and severity of ILD and pulmonary hypertension (PH), with the shortest PBL-TL found in subjects with concurrent ILD and PH (P = 0.04). PBL-TL was not associated with skin disease or peripheral vascular disease. Shorter PBL-TL was associated with hospitalizations (P < 0.01) and worse event-free survival (P = 0.03). Patients with early SSc had a faster rate of PBL-TL shortening compared with patients with longer disease duration (P = 0.04). TL was shorter in SSc-ILD lung epithelial cells (P = 0.01), whereas no difference was found in epithelial cells of SSc skin (P = 0.82).
CONCLUSION: Short PBL-TL is associated with pulmonary disease severity and predicts worse SSc clinical outcomes. This study provides rationale to further investigate the role of telomere dysfunction in SSc pathogenesis and validate TL as a prognostic biomarker in SSc.
METHODS: PBL-TL was measured by quantitative polymerase chain reaction in 244 patients with SSc and 314 healthy controls. Multivariate modeling was used to assess the association of PBL-TL with disease severity and event-free survival. Longitudinal changes in PBL-TL were measured in a subset of patients. TL was quantified in SSc skin and lung tissues by telomere fluorescence in situ hybridization.
RESULTS: PBL-TL was significantly shorter in patients with SSc than healthy controls. Shortened PBL-TL was associated with presence and severity of ILD and pulmonary hypertension (PH), with the shortest PBL-TL found in subjects with concurrent ILD and PH (P = 0.04). PBL-TL was not associated with skin disease or peripheral vascular disease. Shorter PBL-TL was associated with hospitalizations (P < 0.01) and worse event-free survival (P = 0.03). Patients with early SSc had a faster rate of PBL-TL shortening compared with patients with longer disease duration (P = 0.04). TL was shorter in SSc-ILD lung epithelial cells (P = 0.01), whereas no difference was found in epithelial cells of SSc skin (P = 0.82).
CONCLUSION: Short PBL-TL is associated with pulmonary disease severity and predicts worse SSc clinical outcomes. This study provides rationale to further investigate the role of telomere dysfunction in SSc pathogenesis and validate TL as a prognostic biomarker in SSc.