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Войти в исследования Gastrointestinal involvement in very early and established systemic sclerosis: insights from the SPRING-SIR national Italian registry.
Обработка статьи · этапы, ошибки и управление
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Bonomi Francesco, Bruni Cosimo, Peretti Silvia, De Angelis Rossella, Bajocchi Gianluigi, Giuggioli Dilia, Orlandi Martina, Zanframundo Giovanni, Foti Rosario, Cuomo Giovanna, Ariani Alarico, Rosato Edoardo, Lepri Gemma, Girelli Francesco, Riccieri Valeria, Zanatta Elisabetta, Bosello Silvia Laura, Cavazzana Ilaria, Ingegnoli Francesca, De Santis Maria, Cacciapaglia Fabio, Murdaca Giuseppe, Abignano Giuseppina, Giorgio Pettiti, Della Rossa Alessandra, Caminiti Maurizio, Iuliano Anna Maria, Ciano Giovanni, Beretta Lorenzo, Bagnato Gianluca, Lubrano Ennio, De Andres Ilenia, Idolazzi Luca, Saracco Marta, Agnes Cecilia, Campochiaro Corrado, Cipolletta Edoardo, Fornaro Marco, Lumetti Federica, Spinella Amelia, Magnani Luca, De Luca Giacomo, Codullo Veronica, Visalli Elisa, Iandoli Carlo, Gigante Antonietta, Pellegrino Greta, Pigatto Erika, Lazzaroni Maria Grazia, De Lorenzis Enrico, Mennillo Gianna, Di Battista Marco, Pagano-Mariano Giuseppa, Furini Federica, Vultaggio Licia, Parisi Simone, Peroni Clara Lisa, Bianchi Gerolamo, Fusaro Enrico, Sebastiani Gian Domenico, Govoni Marcello, D'Angelo Salvatore, Cozzi Franco, Franceschini Franco, Guiducci Serena, Dagna Lorenzo, Doria Andrea, Salvarani Carlo, D'Agostino Maria Antonietta, Iannone Florenzo, Ferri Clodoveo, Matucci-Cerinic Marco, Bellando Randone Silvia, SPRING-SIR (Systemic Sclerosis PRogression INvestiGation group of the Italian Society for Rheumatology)
Аннотация
METHODS: This cross-sectional analysis included patients fulfilling 2013 ACR/EULAR SSc or VEDOSS criteria. GI involvement was defined as symptoms in at least one GI tract segment and categorized as upper and lower. Associations between GI involvement and clinical variables were assessed using logistic and ordinal regression models, adjusting for demographics, disease characteristics and autoantibodies.
RESULTS: Among 1917 SSc patients, 56% had GI symptoms, associated with longer disease duration, dcSSc, interstitial lung disease (ILD), digital ulcers (DU), telangiectasias and tobacco exposure. Extensive GI involvement correlated with more severe disease. Ordinal regression identified female sex, dcSSc, ILD, DU, telangiectasias, tobacco exposure and anti-centromere antibodies as variables significantly associated with more extensive GI involvement. Disease duration did not show a significant association with GI symptom extent. Among 211 VEDOSS patients, 41.2% reported GI symptoms (mostly oesophageal), significantly associated with puffy fingers and dyspnoea. Among VEDOSS, puffy fingers and anti-centromere antibodies were independent predictors of presence of oesophageal symptoms.
CONCLUSION: GI involvement in SSc is linked to more severe disease and longer disease duration. Disease duration resulted linked to the presence of GI symptoms rather than extent of GI involvement. Puffy fingers and anti-centromere antibodies may associate with presence of early oesophageal symptoms in VEDOSS.