A Study to Asses Effects of Diabetes Mellitus on Treatment Outcome of Tuberculosis Patients.

BACKGROUND

It has been known for a long time that tuberculosis (TB) and Diabetes mellitus (DM) have complex interactions, the mechanisms of which are not completely known yet. TB may have a different presentation in diabetics, and similarly, diabetic status is affected by Tuberculosis and its treatment.

MATERIALS AND

METHODS

A prospective comparative study was conducted on 270 Tuberculosis patients. Diagnosis of tuberculosis was confirmed using Sputum, CBNAAT and imaging modalities. Glycemic control was assessed using Fasting Blood Sugar, Random Blood Sugar, and HbA1c levels. Treatment outcomes was assesed over six months as per standard NTEP guidelines.

RESULTS

In TB with Diabetes group the percentage of males 65% was more as compared to females which was 35%, while in case of TB without Diabetes the percentage of females 54% was more as compared to males 46%. The mean age of TB with Diabetes group was 39.60 ± 15.6 years and in TB without Diabetes group the mean age was 38.73 ± 17.3 years. High treatment failure rate was noted in patients with TB with Diabetes (P < 0.05).

CONCLUSION

There is a two-way relationship between TB and diabetes, and they both affect each other's presentation. Early Diagnosis and glycemic management are essential in improving treatment outcomes.