Более ранний возраст возникновения множественного склероза у азиатских пациентов в северо-восточной части Соединенных Штатов.
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Sheth Manali S, Healy Brian C, Chitnis Tanuja
Аннотация
Оригинал публикации
Earlier age of onset of multiple sclerosis in Asian patients in a Northeastern United States cohort.
BACKGROUND: The clinical course of multiple sclerosis (MS) is influenced by patient demographics, though there is little research on MS in the Asian population in the United States (US). To date, one US-based study suggests that Asian patients in the US have a younger age at symptom onset and diagnosis, and a shorter lag time to diagnosis when compared to non-Asian patients. No studies have compared the clinical course of MS in Asian immigrants and US-born patients.
OBJECTIVE: This study compares the clinical characteristics of MS in Asian patients to Whites at a Northeastern US center, and stratifies Asian patients based on immigrant status.
METHODS: We performed a single-center cross-sectional study, analyzing demographic and clinical data from 6918 patients (6799 White, 119 Asian). The Asian cohort was stratified by place of birth.
RESULTS: Demographic data was largely similar between both groups. Key clinical findings include a younger age at symptom onset (31.1 vs 34.5 years) and diagnosis (33.2 vs 37.6 years) in Asian patients compared to Whites. Accounting for disease duration showed no differences in disability between Whites and Asians. There were no differences between US-born and non-US born Asian patients.
CONCLUSION: This study supports an earlier US-based study that Asian MS patients in the US may have a younger age at onset than white patients. Further research should explore environmental and genetic factors to better understand the underlying pathogenic mechanisms of this finding.