Медицинская библиотека · Rheumatology (Oxford, England) · 2002

Anti-U5 snRNP antibody as a possible serological marker for scleroderma-polymyositis overlap.

Kubo M, Ihn H, Kuwana M, Asano Y, Tamaki T, Yamane K, Tamaki K

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Аннотация

OBJECTIVE

To determine the prevalence of the anti-U5 small nuclear ribonucleoprotein (snRNP) antibody in patients with systemic sclerosis.

METHODS

Sera from 281 patients with systemic sclerosis, including 10 patients with overlapping polymyositis, were assayed using RNA immunoprecipitation and protein immunoprecipitation.

RESULTS

Only one serum sample showed precipitation of U5 snRNA with scarce precipitation of U2, U1, U4 and U6 snRNAs. In addition, the serum precipitated a 200 kDa protein. The serum was from a 35-yr-old Japanese male patient with overlapping systemic sclerosis and polymyositis accompanied by large-cell lung carcinoma. The clinical appearance was similar to that of a case reported previously.

CONCLUSION

The presence of the anti-U5 snRNP antibody in serum may be specific for scleroderma-polymyositis overlap syndrome.

Для цитирования: Kubo M, Ihn H, Kuwana M, Asano Y, Tamaki T, Yamane K, Tamaki K. Anti-U5 snRNP antibody as a possible serological marker for scleroderma-polymyositis overlap.. Rheumatology (Oxford, England). 2002. DOI: 10.1093/rheumatology/41.5.531.

Предметные рубрики MeSH

Adult Antibodies, Antinuclear Biomarkers Carcinoma, Large Cell Carcinoma, Non-Small-Cell Lung Humans Lung Neoplasms Male Polymyositis RNA, Small Nuclear Ribonucleoprotein, U5 Small Nuclear Scleroderma, Systemic

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