Annals of Saudi medicine · 2024
Sex-related differences in Cushing's disease: a systematic review and meta-analysis.
СтатьяМетаанализСистематический обзорНазвание и аннотация: Перевод в очереди
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Alqeeq Basel F, Ayyad Mohammed, Almadhoun Waseem J, Aboabdo Mohammad, Aldahdouh Mosheer S, Al-Tawil Mohammed, Al-Ghazali Ahmed M
Аннотация
BACKGROUND AND OBJECTIVES: Cushing's disease is a rare endocrine disorder. This review aimed to examine sex-specific differences in Cushing's disease.
DESIGN AND SETTINGS: A meta-analysis was performed on published articles discussing the gender impact of Cushing's disease.
METHODS: A systematic search was conducted to identify studies from Medline, Embase, CENTRAL and Scopus. Nine studies enrolling 1047 patients diagnosed with Cushing's disease were included in this meta-analysis.
RESULTS: Male patients presented at a younger age (MD [mean difference]=-5.43; 95% CI [-5.78, -5.08]; P<.00001) than females. Male patients had a significantly higher prevalence of osteoporosis (RR [risk ratio]=1.75; 95% CI [1.36, 225]; P<.0001) and hypokalemia (RR=1.66; 95% CI [1.27, 2.16]; P=.0002). In addition, males had significantly higher rates of negative magnetic resonance imaging (RR=1.53; 95% CI [1.18, 2.0]; P=.002). No sex difference was observed in the prevalence of diabetes (RR=0.92; 95% CI [0.70, 1.22]); P=.57) and dyslipidemia (RR=1.33; 95% CI [0.88, 2.0]; P=.17).
CONCLUSION: Cushing's disease has a worse clinical presentation in males and more diagnostic difficulties compared to females.
DESIGN AND SETTINGS: A meta-analysis was performed on published articles discussing the gender impact of Cushing's disease.
METHODS: A systematic search was conducted to identify studies from Medline, Embase, CENTRAL and Scopus. Nine studies enrolling 1047 patients diagnosed with Cushing's disease were included in this meta-analysis.
RESULTS: Male patients presented at a younger age (MD [mean difference]=-5.43; 95% CI [-5.78, -5.08]; P<.00001) than females. Male patients had a significantly higher prevalence of osteoporosis (RR [risk ratio]=1.75; 95% CI [1.36, 225]; P<.0001) and hypokalemia (RR=1.66; 95% CI [1.27, 2.16]; P=.0002). In addition, males had significantly higher rates of negative magnetic resonance imaging (RR=1.53; 95% CI [1.18, 2.0]; P=.002). No sex difference was observed in the prevalence of diabetes (RR=0.92; 95% CI [0.70, 1.22]); P=.57) and dyslipidemia (RR=1.33; 95% CI [0.88, 2.0]; P=.17).
CONCLUSION: Cushing's disease has a worse clinical presentation in males and more diagnostic difficulties compared to females.