Postepy dermatologii i alergologii · 2014
Frequency of IgE-dependent hypersensitivity to moulds in patients with chronic rhinosinusitis with polyps.
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Gawlik Radosław, Czecior Eugeniusz, Jarząb Jerzy, Grzanka Alicja, Cichecka Ewelina, Sowa Paweł, Scierski Wojciech
Аннотация
OBJECTIVES: Pulmonary arterial hypertension (PAH) is a frequent and severe complication of systemic sclerosis (SSc). Despite the improvements achieved in recent decades, PAH remains a cause of significant clinical burden, and treatment mainly relies on a combination of vasodilatory and anti-proliferative agents, following the same therapeutic approach used for idiopathic PAH.
METHODS: We retrospectively analysed the records of 607 patients reviewed in our centre. PAH was defined as pre-capillary pulmonary hypertension (mPAP ≥ 25mmHg, PVR >3WU, PCWP <15mmHg) in absence of significant hypoxic component (patients with clinically significant airway disease, or with interstitial lung disease and FVC <70%, were excluded from PAH group). Early immunosuppression (IS) was defined as treatment within the first 5 years after SSc onset with conventional or biologic disease-modifying anti-rheumatic drugs (DMARDs), or a prednisone-equivalent dose ≥10mg/day.
RESULTS: Out of 607 patients, 77 received a diagnosis of PAH. Early immunosuppression was not associated with reduced odds of developing PAH (OR 0.74, p=0.495). However, when analysing individual immunosuppressive agents, early treatment with mycophenolate mofetil was associated with a significant protective effect (OR 0.12; p=0.048). Immunosuppressive treatment was associated with a significant reduction in mortality risk (HR 0.41; p= 0.045), attributable to the effect of hydroxychloroquine, which was the only agent showing an impact on survival (HR 0.04; p= 0.004).
CONCLUSIONS: In this retrospective monocentric study early treatment with mycophenolate was associated with reduced odds of developing SSc-PAH, while treatment with hydroxychloroquine showed a significant improvement in survival in patients with established SSc-PAH.
METHODS: We retrospectively analysed the records of 607 patients reviewed in our centre. PAH was defined as pre-capillary pulmonary hypertension (mPAP ≥ 25mmHg, PVR >3WU, PCWP <15mmHg) in absence of significant hypoxic component (patients with clinically significant airway disease, or with interstitial lung disease and FVC <70%, were excluded from PAH group). Early immunosuppression (IS) was defined as treatment within the first 5 years after SSc onset with conventional or biologic disease-modifying anti-rheumatic drugs (DMARDs), or a prednisone-equivalent dose ≥10mg/day.
RESULTS: Out of 607 patients, 77 received a diagnosis of PAH. Early immunosuppression was not associated with reduced odds of developing PAH (OR 0.74, p=0.495). However, when analysing individual immunosuppressive agents, early treatment with mycophenolate mofetil was associated with a significant protective effect (OR 0.12; p=0.048). Immunosuppressive treatment was associated with a significant reduction in mortality risk (HR 0.41; p= 0.045), attributable to the effect of hydroxychloroquine, which was the only agent showing an impact on survival (HR 0.04; p= 0.004).
CONCLUSIONS: In this retrospective monocentric study early treatment with mycophenolate was associated with reduced odds of developing SSc-PAH, while treatment with hydroxychloroquine showed a significant improvement in survival in patients with established SSc-PAH.