Journal of ethnopharmacology · 2026
Illicium verum extract attenuates immobilization-induced muscle atrophy by modulating inflammatory and anabolic pathways.
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Yoo Jihee, Kim Mi-Bo, Moon Chae Young, Kang Hyunju, Hwang Jae-Kwan
Аннотация
ETHNOPHARMACOLOGICAL RELEVANCE: Illicium verum Hook. f. (star anise) is traditionally used in Chinese medicine to warm the interior and regulate qi flow to treat functional imbalances. While implying a role in restoring homeostasis, its therapeutic potential against skeletal muscle atrophy, characterized by metabolic and inflammatory disruption, remains scientifically unverified.
AIM OF THE STUDY: This study investigated the therapeutic effects of I. verum hot water extract (IVW) against muscle atrophy using tumor necrosis factor-α (TNF-α)-stimulated myotubes and an immobilization-induced mouse model.
MATERIALS AND METHODS: IVW, chemically characterized with shikimic acid as a marker, was evaluated in TNF-α-stimulated L6 myotubes and C57BL/6J mice subjected to 7-day hindlimb immobilization followed by oral administration. Muscle mass, function, and key signaling pathways governing protein synthesis and degradation were analyzed.
RESULTS: IVW treatment significantly preserved muscle mass, myofiber cross-sectional area, grip strength, and exercise endurance in immobilized mice. Mechanistically, IVW reactivated anabolic signaling mediated by phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt)/mammalian target of rapamycin (mTOR), while suppressing inflammation driven by nuclear factor-κB (NF-κB) and ubiquitin-proteasome degradation dependent on forkhead box O3a (FoxO3a) in both models.
CONCLUSIONS: IVW mitigates immobilization-induced atrophy, associated with the dual regulation of anabolic and catabolic pathways. These findings provide a modern pharmacological basis for the traditional use of I. verum in treating functional imbalances, highlighting its potential as a candidate for managing disuse-induced muscle wasting.
AIM OF THE STUDY: This study investigated the therapeutic effects of I. verum hot water extract (IVW) against muscle atrophy using tumor necrosis factor-α (TNF-α)-stimulated myotubes and an immobilization-induced mouse model.
MATERIALS AND METHODS: IVW, chemically characterized with shikimic acid as a marker, was evaluated in TNF-α-stimulated L6 myotubes and C57BL/6J mice subjected to 7-day hindlimb immobilization followed by oral administration. Muscle mass, function, and key signaling pathways governing protein synthesis and degradation were analyzed.
RESULTS: IVW treatment significantly preserved muscle mass, myofiber cross-sectional area, grip strength, and exercise endurance in immobilized mice. Mechanistically, IVW reactivated anabolic signaling mediated by phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt)/mammalian target of rapamycin (mTOR), while suppressing inflammation driven by nuclear factor-κB (NF-κB) and ubiquitin-proteasome degradation dependent on forkhead box O3a (FoxO3a) in both models.
CONCLUSIONS: IVW mitigates immobilization-induced atrophy, associated with the dual regulation of anabolic and catabolic pathways. These findings provide a modern pharmacological basis for the traditional use of I. verum in treating functional imbalances, highlighting its potential as a candidate for managing disuse-induced muscle wasting.