Frontiers in nutrition · 2026
Impact of metabolic score for visceral fat on bone health in adolescent population: a cross-sectional study perspective.
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Chen Linlin, Liu Jianxi, Shi Longkai, Xu Yingli, Ding Wenqing
Аннотация
OBJECTIVE: To analyze the relationship between the Metabolic Score for Visceral Fat (METS-VF), bone mineral content (BMC), and bone metabolism indexes in Chinese adolescents.
METHODS: This cross-sectional study used stratified cluster sampling to select 1,206 adolescents (12-18 years) from six schools in Yinchuan (2017-2023). Body composition and BMC of the participants were measured using bioelectrical impedance analysis (BIA). Serum bone metabolism indexes [osteocalcin (OC) and C-terminal telopeptide of type I collagen (CTX)] were measured.
RESULTS: METS-VF was found to be associated with BMC (r = 0.484, P < 0.001) and OC (r = -0.074, P = 0.010), but not with CTX (r = 0.042, P = 0.141). After adjusting for confounding factors, compared with the lowest quartile of METS-VF, the risk of low BMC in the highest quartile was significantly lower, with an OR of 0.17 (95% CI: 0.05-0.49), whereas the risk of low OC was significantly higher, with an OR of 3.47 (95% CI: 1.82-6.59) (all P < 0.05). In sex-stratified analyses, this association was significant in both boys and girls (ORboys = 0.03, 95% CI: 0.01-0.46, P = 0.007; ORgirls = 0.20, 95% CI: 0.06-0.64, P = 0.005). Restricted cubic spline curves indicated that there was an inverted U-shaped non-linear relationship between METS-VF and BMC (P-overall = 0.002, P-nonlinear = 0.009). In sex-stratified analyses, the association was significant in girls (P-nonlinear = 0.152; P-overall = 0.008); Moreover, linear relationship between METS-VF and OC were found (P nonlinear = 0.162, P-overall <0.05). Receiver operating characteristic (ROC) curves showed that METS-VF had modest discriminatory ability for low BMC better than VAI and TyG (AUC = 0.641, 95% CI = 0.605-0.678, P < 0.05).
CONCLUSION: Our findings suggest a non-linear association between METS-VF and BMC in adolescents, and fat distribution and content were more closely related to bone metabolism.
METHODS: This cross-sectional study used stratified cluster sampling to select 1,206 adolescents (12-18 years) from six schools in Yinchuan (2017-2023). Body composition and BMC of the participants were measured using bioelectrical impedance analysis (BIA). Serum bone metabolism indexes [osteocalcin (OC) and C-terminal telopeptide of type I collagen (CTX)] were measured.
RESULTS: METS-VF was found to be associated with BMC (r = 0.484, P < 0.001) and OC (r = -0.074, P = 0.010), but not with CTX (r = 0.042, P = 0.141). After adjusting for confounding factors, compared with the lowest quartile of METS-VF, the risk of low BMC in the highest quartile was significantly lower, with an OR of 0.17 (95% CI: 0.05-0.49), whereas the risk of low OC was significantly higher, with an OR of 3.47 (95% CI: 1.82-6.59) (all P < 0.05). In sex-stratified analyses, this association was significant in both boys and girls (ORboys = 0.03, 95% CI: 0.01-0.46, P = 0.007; ORgirls = 0.20, 95% CI: 0.06-0.64, P = 0.005). Restricted cubic spline curves indicated that there was an inverted U-shaped non-linear relationship between METS-VF and BMC (P-overall = 0.002, P-nonlinear = 0.009). In sex-stratified analyses, the association was significant in girls (P-nonlinear = 0.152; P-overall = 0.008); Moreover, linear relationship between METS-VF and OC were found (P nonlinear = 0.162, P-overall <0.05). Receiver operating characteristic (ROC) curves showed that METS-VF had modest discriminatory ability for low BMC better than VAI and TyG (AUC = 0.641, 95% CI = 0.605-0.678, P < 0.05).
CONCLUSION: Our findings suggest a non-linear association between METS-VF and BMC in adolescents, and fat distribution and content were more closely related to bone metabolism.