Медицинская библиотека · Rheumatology (Oxford, England) · 2000

Serum KL-6 in adult patients with polymyositis and dermatomyositis.

Kubo M, Ihn H, Yamane K, Kikuchi K, Yazawa N, Soma Y, Tamaki K

СтатьяПоддержка исследования: вне правительства СШАПеревод в очереди

Аннотация

OBJECTIVE

To determine the serum levels of KL-6, a mucin-like high-molecular-weight glycoprotein, in polymyositis/dermatomyositis (PM/DM) patients.

METHODS

Serum samples from 42 adult PM/DM patients and 38 healthy control subjects were examined using specific enzyme-linked immunosorbent assay (ELISA) systems.

RESULTS

The serum levels of KL-6 in the PM/DM patients were significantly higher than those of the healthy controls. The elevated serum KL-6 levels correlated with the presence of interstitial lung disease (ILD) and decreased percentage diffusing capacity of carbon monoxide (%DLco) in the PM/DM patients. The serum KL-6 levels inversely correlated with %DLco and percentage vital capacity. Additionally, the serum KL-6 levels were elevated in five of the seven DM patients with malignant neoplasia.

CONCLUSIONS

These results suggest that the serum KL-6 level might be a useful serum marker for ILD and internal malignancy in PM/DM.

Для цитирования: Kubo M, Ihn H, Yamane K, Kikuchi K, Yazawa N, Soma Y, Tamaki K. Serum KL-6 in adult patients with polymyositis and dermatomyositis.. Rheumatology (Oxford, England). 2000. DOI: 10.1093/rheumatology/39.6.632.

Предметные рубрики MeSH

Adult Aged Antigens Antigens, Neoplasm Dermatomyositis Enzyme-Linked Immunosorbent Assay Female Glycoproteins Humans Male Middle Aged Mucin-1 Mucins Neoplasms Polymyositis

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