Proceedings of the National Academy of Sciences of the United States of America · 2018
Nitro-fatty acids are formed in response to virus infection and are potent inhibitors of STING palmitoylation and signaling.
СтатьяПоддержка NIH: внешняя программаПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Hansen Anne Louise, Buchan Gregory J, Rühl Michael, Mukai Kojiro, Salvatore Sonia R, Ogawa Emari, Andersen Sidsel D, Iversen Marie B, Thielke Anne L, Gunderstofte Camilla, Motwani Mona, Møller Charlotte T, Jakobsen Andreas S, Fitzgerald Katherine A, Roos Jessica, Lin Rongtuan, Maier Thorsten J, Goldbach-Mansky Raphaela, Miner Cathrine A, Qian Wei, Miner Jonathan J, Rigby Rachel E, Rehwinkel Jan, Jakobsen Martin R, Arai Hiroyuki, Taguchi Tomohiko, Schopfer Francisco J, Olagnier David, Holm Christian K
Аннотация
The adaptor molecule stimulator of IFN genes (STING) is central to production of type I IFNs in response to infection with DNA viruses and to presence of host DNA in the cytosol. Excessive release of type I IFNs through STING-dependent mechanisms has emerged as a central driver of several interferonopathies, including systemic lupus erythematosus (SLE), Aicardi-Goutières syndrome (AGS), and stimulator of IFN genes-associated vasculopathy with onset in infancy (SAVI). The involvement of STING in these diseases points to an unmet need for the development of agents that inhibit STING signaling. Here, we report that endogenously formed nitro-fatty acids can covalently modify STING by nitro-alkylation. These nitro-alkylations inhibit STING palmitoylation, STING signaling, and subsequently, the release of type I IFN in both human and murine cells. Furthermore, treatment with nitro-fatty acids was sufficient to inhibit production of type I IFN in fibroblasts derived from SAVI patients with a gain-of-function mutation in STING. In conclusion, we have identified nitro-fatty acids as endogenously formed inhibitors of STING signaling and propose for these lipids to be considered in the treatment of STING-dependent inflammatory diseases.