Digestive diseases and sciences · 2022
Upadacitinib Is Safe and Effective for Crohn's Disease: Real-World Data from a Tertiary Center.
СтатьяНазвание и аннотация: Перевод в очереди
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Traboulsi Cindy, Ayoub Fares, Silfen Alexa, Rodriguez Tina G, Rubin David T
Аннотация
Upadacitinib is a selective JAK-1 inhibitor approved for the treatment of rheumatoid arthritis and more recently, ulcerative colitis. Phase II trials demonstrated that upadacitinib induces endoscopic remission in patients with moderate-to-severe Crohn's disease. However, real-world data are lacking. We present a short report on our experience with off-label upadacitinib in patients with CD at a tertiary center. In this cohort of medically refractory patients with CD, treatment with upadacitinib resulted in subjective and objective responses in 25 and 42% of patients, respectively. Even at doses that are considered lower than currently being studied for CD, upadacitinib was associated with a favorable benefit-to-risk profile.