Medicine · 2021
Acute retrobulbar optic neuritis with anti-myelin oligodendrocyte glycoprotein antibody-associated disease complicated with microscopic polyangiitis: A case report.
Клинический случайСтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Asano Tomoyuki, Saito Yuzuka, Matsuoka Naoki, Temmoku Jumpei, Fujita Yuya, Hattori Kasumi, Kobayashi Shunsuke, Ojima Akira, Takahashi Toshiyuki, Matsumoto Haruki, Yashiro-Furuya Makiko, Sato Shuzo, Kobayashi Hiroko, Watanabe Hiroshi, Yano Kiori, Sasajima Tomomi, Fujihara Kazuo, Migita Kiyoshi
Аннотация
RATIONALE: Anti-myelin oligodendrocyte protein antibody-associated disease (MOGAD) is a new disease entity with various clinical phenotypes. MOGAD often present with recurrent optic neuritis (ON), and it can also develop as a compartment of neuromyelitis optica spectrum disorder (NMOSD). Moreover, multiple autoantibodies such as an anti-myeloperoxidase antineutrophil cytoplasmic antibody (MPO-ANCA) had been reported in the serum of patients with NMOSD.
PATIENT CONCERNS: We report an 86-year-old woman with a 2-year history of microscopic polyangiitis (MPA). The patient had a rapid loss of vision in her left eye. No abnormal findings were observed on her left fundus, and she tested negative for MPO-ANCA upon admission. However, anti-MOG antibodies were observed in the patient's serum and cerebrospinal fluid.
DIAGNOSIS: A diagnosis of MOGAD complicated with MPA was made.
INTERVENTIONS: The patient received twice steroid pulse therapy and oral azathioprine as maintenance therapy.
OUTCOMES: Her vision rapidly recovered, and no subsequent relapse was observed during the 8-month observation period.
CONCLUSION: To the best of our knowledge, this is the first case of MOGAD complicated with MPA, and steroid pulse therapy and azathioprine therapy were effective for ON caused by MOGAD.
PATIENT CONCERNS: We report an 86-year-old woman with a 2-year history of microscopic polyangiitis (MPA). The patient had a rapid loss of vision in her left eye. No abnormal findings were observed on her left fundus, and she tested negative for MPO-ANCA upon admission. However, anti-MOG antibodies were observed in the patient's serum and cerebrospinal fluid.
DIAGNOSIS: A diagnosis of MOGAD complicated with MPA was made.
INTERVENTIONS: The patient received twice steroid pulse therapy and oral azathioprine as maintenance therapy.
OUTCOMES: Her vision rapidly recovered, and no subsequent relapse was observed during the 8-month observation period.
CONCLUSION: To the best of our knowledge, this is the first case of MOGAD complicated with MPA, and steroid pulse therapy and azathioprine therapy were effective for ON caused by MOGAD.