Circulation research · 2025
Human Hearts Intrinsically Increase Cardiomyocyte Mitosis After Myocardial Infarction.
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Hume Robert D, Warwick Jessica, Shim Woo Jun, Malecki Cassandra, Li Mengbo, Seth Lakshay, Harney Dylan, Dagher Julien, Lum Trina, Tierney Geraldine, Cooper Wendy, Slaughter Eugene, Wang Xiaosuo, Nguyen Lisa, Cole Louise, Edelman James, Rashid Fairooj N, Houlahan Callum, Gao Antony, Ferguson Angela L, Chong James J H, Larance Mark, O'Sullivan John F, Palpant Nathan J, Bannon Paul, Lal Sean
Аннотация
BACKGROUND: Myocardial infarction (MI) is a leading cause of death worldwide and can eliminate up to a third of the cardiomyocytes within the human heart. Although cardiomyocytes undergo mitosis during early development, most cardiomyocytes cease cell cycling soon after birth. In contrast, rodent MI models have shown that cardiomyocytes increase mitosis in response to ischemia; however, this has not been shown in humans.
METHODS: Using a unique premortem post-MI human heart, immunostaining, bulk RNA sequencing, proteomics, metabolomics, single-nucleus RNA sequencing and a novel post-MI human biopsy method, we investigated human cardiomyocyte mitosis post-MI.
RESULTS: We show that adult human cardiomyocytes exhibit increased mitosis and cytokinesis in response to ischemia.
CONCLUSIONS: Future development of therapeutics to enhance this intrinsic mitotic potential could lead to new treatments that reverse heart failure via cardiac regeneration.
METHODS: Using a unique premortem post-MI human heart, immunostaining, bulk RNA sequencing, proteomics, metabolomics, single-nucleus RNA sequencing and a novel post-MI human biopsy method, we investigated human cardiomyocyte mitosis post-MI.
RESULTS: We show that adult human cardiomyocytes exhibit increased mitosis and cytokinesis in response to ischemia.
CONCLUSIONS: Future development of therapeutics to enhance this intrinsic mitotic potential could lead to new treatments that reverse heart failure via cardiac regeneration.