BMC public health · 2025
Malaria misdiagnosis substantially contributes to the underestimation of global human brucellosis incidence.
СтатьяНазвание и аннотация: Перевод в очереди
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Laine Christopher G, Johnson Valen E, Scott H Morgan, Arenas-Gamboa Angela M
Аннотация
BACKGROUND: Brucellosis is a neglected and re-emerging zoonotic disease of nearly worldwide distribution. Recently, a new model utilizing publicly available data, voluntarily provided by countries to the World Organization for Animal Health (WOAH), estimated a global annual incidence of at least 1.62-2.10 million cases. However, global and regional knowledge gaps, partially attributed to lack of diagnostic capability and disease unawareness, result in misdiagnosis.
METHODS: This study incorporated misdiagnosis to assess the potential impact on incidence estimates. Specifically, we examined the potential impact of misdiagnosing brucellosis as malaria. Incidence rates modeled from WOAH data comprised a baseline estimate for brucellosis rates. A range of potential misdiagnosis rates based on World Bank malaria data and scientific literature were utilized to estimate the number of misdiagnosed cases. We assumed a conservative misdiagnosis range of 0.25-4.00% based on clinical studies that reported a 4-11% misdiagnosis rate.
RESULTS: We show that malaria misdiagnosis can significantly impact global annual incidence estimation of brucellosis. Rates of 0.25% increase brucellosis incidence by 0.34-5.4 M cases, while rates of 4% increase these estimates by 2.43-7.45 M cases.
CONCLUSIONS: Human brucellosis misdiagnosed as malaria can significantly impact global annual incidence estimates. Enhanced efforts are needed to identify misdiagnosed cases in countries where both diseases are endemic.
METHODS: This study incorporated misdiagnosis to assess the potential impact on incidence estimates. Specifically, we examined the potential impact of misdiagnosing brucellosis as malaria. Incidence rates modeled from WOAH data comprised a baseline estimate for brucellosis rates. A range of potential misdiagnosis rates based on World Bank malaria data and scientific literature were utilized to estimate the number of misdiagnosed cases. We assumed a conservative misdiagnosis range of 0.25-4.00% based on clinical studies that reported a 4-11% misdiagnosis rate.
RESULTS: We show that malaria misdiagnosis can significantly impact global annual incidence estimation of brucellosis. Rates of 0.25% increase brucellosis incidence by 0.34-5.4 M cases, while rates of 4% increase these estimates by 2.43-7.45 M cases.
CONCLUSIONS: Human brucellosis misdiagnosed as malaria can significantly impact global annual incidence estimates. Enhanced efforts are needed to identify misdiagnosed cases in countries where both diseases are endemic.