[Role of genetic factors in the development of osteoporosis].

Osteoporosis which often accompanies the normal aging and a number of pathological conditions is closely related to bone remodeling disturbances. This process is provided mainly by the genesis of osteoblasts and osteoclasts, their activities and interactions. All the above in turn is dependent on numerous systemic and local regulatory factors such as hormones, nutrients, minerals, vitamins, cytokines, their receptors etc. Recently the crucial role of genetic polymorphism of many receptors in bone remodeling, bone loss and susceptibility to osteoporosis development has been shown. This review is devoted to the genetic background of interrelationships among the hormones, cytokines, vitamins and their receptors and discussion of possible sources of discrepancies in data obtained by many authors who studied populations like genetic, diet, life-styles and environmental influences.