Scientific reports · 2017
Mechanical stress induces elastic fibre disruption and cartilage matrix increase in ligamentum flavum.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
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Ошибки и ограничения
История · было → стало
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Hayashi Kazunori, Suzuki Akinobu, Abdullah Ahmadi Sayed, Terai Hidetomi, Yamada Kentaro, Hoshino Masatoshi, Toyoda Hiromitsu, Takahashi Shinji, Tamai Koji, Ohyama Shoichiro, Javid Akgar, Suhrab Rahmani Mohammad, Hasib Maruf Mohammad, Nakamura Hiroaki
Аннотация
Lumbar spinal stenosis (LSS) is one of the most frequent causes of low back pain and gait disturbance in the elderly. Ligamentum flavum (LF) hypertrophy is the main pathomechanism of LSS, but the reason for its occurrence is not clearly elucidated. In this study, we established a novel animal model of intervertebral mechanical stress concentration and investigated the biological property of the LF. The LF with mechanical stress concentration showed degeneration with elastic fibres disruption and cartilage matrix increase, which are similar to the findings in hypertrophied LF from patients with LSS. By contrast, decreased Col2a1 expression was found in the LF at fixed levels, in which mechanical stress was strongly reduced. These findings indicate that mechanical stress plays a crucial role in LF hypertrophy through cartilage matrix increase. The findings also suggest that fusion surgery, which eliminates intervertebral instability, may change the property of the LF and lead to the relief of patients' symptoms.