Frontiers in oncology · 2026
Capillary hemangioma involving both intracranial and entire spinal dura: a case report.
Клинический случайСтатьяНазвание и аннотация: Перевод в очереди
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Wei Zixuan, Zhang Jibo, Li Huan, Xu Chengshi, Chen Jincao
Аннотация
BACKGROUND: Capillary hemangiomas of the central nervous system are exceedingly rare. Previously documented cases have predominantly been located in the intracranial or spinal regions, with the majority presenting as solitary focal lesions.
CASE DESCRIPTION: A 57-year-old woman complained back pain, urinary problems, and numbness and weakness in the lower extremities. MRI revealed thickening and enhancement of the entire spinal dura mater, anomalous enhancement signals surrounding cerebral blood vessels, and DSA revealed multiple malformed vascular clusters in the intracranial and spinal cord regions. Subsequently, a dural biopsy confirmed the pathological diagnosis of capillary hemangioma, with further whole-genome sequencing to identify potential gene mutations.
CONCLUSIONS: Central nervous system capillary hemangiomas can affect the entire spinal cord and intracranial meningeal tissues simultaneously. Genetic alterations, including PDE4DIP mutations, were identified, but their clinical significance remains unclear.
CASE DESCRIPTION: A 57-year-old woman complained back pain, urinary problems, and numbness and weakness in the lower extremities. MRI revealed thickening and enhancement of the entire spinal dura mater, anomalous enhancement signals surrounding cerebral blood vessels, and DSA revealed multiple malformed vascular clusters in the intracranial and spinal cord regions. Subsequently, a dural biopsy confirmed the pathological diagnosis of capillary hemangioma, with further whole-genome sequencing to identify potential gene mutations.
CONCLUSIONS: Central nervous system capillary hemangiomas can affect the entire spinal cord and intracranial meningeal tissues simultaneously. Genetic alterations, including PDE4DIP mutations, were identified, but their clinical significance remains unclear.