Therapeutic advances in musculoskeletal disease · 2025
Vertebral fractures and bone health in patients with chronic non-bacterial osteomyelitis at disease onset: insights from the monocentric CAMELOT cohort.
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Chighizola Cecilia Beatrice, Di Taranto Raffaele, Amati Andrea, Pireddu Debora, Costi Stefania, Baldo Francesco, Crotti Chiara, Trezza Paolo, Armiraglio Elisabetta, Bartoli Maria Serena, Varenna Massimo, Memeo Antonio, Bastoni Stefano, Marino Achille, Parafioriti Antonina, Caporali Roberto
Аннотация
BACKGROUND: Chronic non-bacterial osteomyelitis (CNO) is a rare autoinflammatory disease characterized by bone pain and sterile bone inflammation.
OBJECTIVES: This study aimed at describing clinical presentation, laboratory and imaging features, densitometric assessment, and therapeutic approaches in a monocentric CNO cohort.
DESIGN: Monocentric retrospective cohort study.
METHODS: Patients were included in the Chronic non-bActerial osteoMyELitis: A mOnocentric regisTry (CAMELOT) in case of (i) clinical diagnosis of CNO, (ii) the fulfilment of diagnostic/classification criteria, (iii) at least one medical visit at our institution between June 2004 and June 2024, and (iv) a follow-up of at least 3 months.
RESULTS: Fifty-one patients were included in the CAMELOT (mean age at onset 11.14 years, 68.6% females). A total of 39.2% of patients presented an autoimmune comorbidity. Bone pain was invariably present; joint involvement was demonstrated in 9.6% of patients. Most subjects (86.3%) had multifocal disease: the median number of bony lesions per patient was 4. Lumbar spine dual-energy X-ray absorptiometry (DXA) was performed in 14 patients (27.4%), showing a reduced bone mineral density (BMD) (-1.14 ± 1.21 Z-score). A total of 18 patients (35.3%) experienced a fracture on a bony lesional site; 14 patients (27.4%) presented vertebral fractures (VFs) at onset, with multiple VFs in 5 cases (35.7%). BMD Z-scores (-1.7 vs -0.5) were lower in patients with VFs, with a higher rate of "low BMD for age" (37.5% vs 16.7%) compared to patients without VFs.
CONCLUSION: The high prevalence of VF observed in the CAMELOT cohort highlights the importance of enlisting CNO in the diagnostic approach to pediatric patients presenting with VF.
OBJECTIVES: This study aimed at describing clinical presentation, laboratory and imaging features, densitometric assessment, and therapeutic approaches in a monocentric CNO cohort.
DESIGN: Monocentric retrospective cohort study.
METHODS: Patients were included in the Chronic non-bActerial osteoMyELitis: A mOnocentric regisTry (CAMELOT) in case of (i) clinical diagnosis of CNO, (ii) the fulfilment of diagnostic/classification criteria, (iii) at least one medical visit at our institution between June 2004 and June 2024, and (iv) a follow-up of at least 3 months.
RESULTS: Fifty-one patients were included in the CAMELOT (mean age at onset 11.14 years, 68.6% females). A total of 39.2% of patients presented an autoimmune comorbidity. Bone pain was invariably present; joint involvement was demonstrated in 9.6% of patients. Most subjects (86.3%) had multifocal disease: the median number of bony lesions per patient was 4. Lumbar spine dual-energy X-ray absorptiometry (DXA) was performed in 14 patients (27.4%), showing a reduced bone mineral density (BMD) (-1.14 ± 1.21 Z-score). A total of 18 patients (35.3%) experienced a fracture on a bony lesional site; 14 patients (27.4%) presented vertebral fractures (VFs) at onset, with multiple VFs in 5 cases (35.7%). BMD Z-scores (-1.7 vs -0.5) were lower in patients with VFs, with a higher rate of "low BMD for age" (37.5% vs 16.7%) compared to patients without VFs.
CONCLUSION: The high prevalence of VF observed in the CAMELOT cohort highlights the importance of enlisting CNO in the diagnostic approach to pediatric patients presenting with VF.