Acupuncture in medicine : journal of the British Medical Acupuncture Society · 2026
Electroacupuncture ameliorates ovariectomy-induced osteoporosis by modulating ferroptosis via the SLC7A11/GPX4 axis.
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Zhang Chuchu, Ouyang Gang
Аннотация
OBJECTIVE: This aim of the study was to investigate whether electroacupuncture (EA) can mitigate osteoporosis (OP) in an ovariectomy (OVX)-induced rat model by affecting the ferroptosis-related pathway.
METHODS: Thirty-two 12-week-old female Sprague-Dawley rats were randomly allocated into four groups: CONTROL, SHAM, OVX and EA. We examined the effects of OVX and EA on markers of bone resorption and formation, iron content, malondialdehyde (MDA) levels, and the expression of ferritin heavy chain 1 (FTH1), solute carrier family 7 member 11 (SLC7A11) and glutathione peroxidase 4 (GPX4). In addition, femoral morphology and immunofluorescence were analysed.
RESULTS: The OVX group exhibited a significant increase in bone resorption markers, iron and MDA levels, with a notable decrease in alkaline phosphatase (ALP) levels, FTH1, SLC7A11 and GPX4 expression, and impaired trabecular architecture. EA significantly reduced bone resorption markers, iron and MDA content while substantially elevating ALP levels and FTH1, SLC7A11 and GPX4 expression. At the same time, EA improved trabecular architecture.
CONCLUSION: EA ameliorated OVX-induced OP by decreasing iron accumulation and activating the SLC7A11/GPX4 axis.
METHODS: Thirty-two 12-week-old female Sprague-Dawley rats were randomly allocated into four groups: CONTROL, SHAM, OVX and EA. We examined the effects of OVX and EA on markers of bone resorption and formation, iron content, malondialdehyde (MDA) levels, and the expression of ferritin heavy chain 1 (FTH1), solute carrier family 7 member 11 (SLC7A11) and glutathione peroxidase 4 (GPX4). In addition, femoral morphology and immunofluorescence were analysed.
RESULTS: The OVX group exhibited a significant increase in bone resorption markers, iron and MDA levels, with a notable decrease in alkaline phosphatase (ALP) levels, FTH1, SLC7A11 and GPX4 expression, and impaired trabecular architecture. EA significantly reduced bone resorption markers, iron and MDA content while substantially elevating ALP levels and FTH1, SLC7A11 and GPX4 expression. At the same time, EA improved trabecular architecture.
CONCLUSION: EA ameliorated OVX-induced OP by decreasing iron accumulation and activating the SLC7A11/GPX4 axis.