Archives of osteoporosis · 2025
Association of low-sodium salt intervention with osteoporosis: A cross-sectional study based on the SSaSS study.
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Li Xilei, Wang Xin, Peng Yuyi, Xia Qiu, Lu Yue, Sun Hao, Zhou Bo
Аннотация
UNLABELLED: Low-sodium salt has a protective effect on BMD and also reduces the risk of osteopenia due to elevated blood glucose. This provides a direct and effective way to improve bone health in patients with hyperglycemia.
OBJECTIVE: There is no consensus on the relationship between salt type and bone mineral density (BMD). This study examined the factors affecting osteoporosis and the relationship between low-sodium salt consumption with osteoporosis based on the Substitute Salt and Stroke Study (SSaSS).
METHODS: This study was a cross-sectional study and compares the prevalence and characteristics of osteoporosis and osteopenia. Multiple linear regression and restricted spline models were used to analyze the factors affecting BMD and its dose-response relationship with osteoporosis and to compare the effects of different salts.
RESULTS: The rates of osteoporosis and osteopenia were lower in those consuming low-sodium salt (31.11% and 38.52%) than in those consuming normal salt (38.65% and 41.10%). BMD was higher in the population consuming low-sodium salt than in that using normal salt (= 0.64, 95%CI: 0.25, 0.97). Age, gender, and blood glucose level interacted with low-sodium salt and together affected BMD. Analysis of the dose-response relationship revealed a positive linear association between elevated blood glucose and the risk of osteopenia (P for overall < 0.05, P for nonlinear = 0.77), but intake of low-sodium salt significantly reduced this risk. The risk of OP increased with age (P for overall < 0.05, P for nonlinear = 0.72); low-sodium salt intake reduced this risk, with the effect being more pronounced among individuals < 70 years old.
CONCLUSION: Low-sodium salt has a positive effect on maintaining BMD. Elevated blood glucose and age < 70 years increase the risk of osteoporosis, but use of low-sodium salt mitigates this risk.
OBJECTIVE: There is no consensus on the relationship between salt type and bone mineral density (BMD). This study examined the factors affecting osteoporosis and the relationship between low-sodium salt consumption with osteoporosis based on the Substitute Salt and Stroke Study (SSaSS).
METHODS: This study was a cross-sectional study and compares the prevalence and characteristics of osteoporosis and osteopenia. Multiple linear regression and restricted spline models were used to analyze the factors affecting BMD and its dose-response relationship with osteoporosis and to compare the effects of different salts.
RESULTS: The rates of osteoporosis and osteopenia were lower in those consuming low-sodium salt (31.11% and 38.52%) than in those consuming normal salt (38.65% and 41.10%). BMD was higher in the population consuming low-sodium salt than in that using normal salt (= 0.64, 95%CI: 0.25, 0.97). Age, gender, and blood glucose level interacted with low-sodium salt and together affected BMD. Analysis of the dose-response relationship revealed a positive linear association between elevated blood glucose and the risk of osteopenia (P for overall < 0.05, P for nonlinear = 0.77), but intake of low-sodium salt significantly reduced this risk. The risk of OP increased with age (P for overall < 0.05, P for nonlinear = 0.72); low-sodium salt intake reduced this risk, with the effect being more pronounced among individuals < 70 years old.
CONCLUSION: Low-sodium salt has a positive effect on maintaining BMD. Elevated blood glucose and age < 70 years increase the risk of osteoporosis, but use of low-sodium salt mitigates this risk.