Maturitas · 2026
Associations of mortality with leisure-time physical activity and sitting time in postmenopausal women: Insights from NHANES.
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Yang Mu, Huang Huayao, Fang Shuangfang, Chen Qingfa, Zhang Yixian, Hou Yiwei, Huang Huapin, Liu Nan, Du Houwei
Аннотация
OBJECTIVE: Postmenopausal women are vulnerable to insufficient physical activity and prolonged sitting. While both behaviors have been individually associated with mortality, their joint effects remain unclear.
METHODS: We analyzed 5355 postmenopausal women (median age 63 years [interquartile range 56-71]) from the National Health and Nutrition Examination Survey (NHANES) 2007-2018. Leisure-time physical activity was categorized as insufficient (<600 metabolic equivalent of task minutes per week) or sufficient (≥600 metabolic equivalent of task minutes per week). Sitting time was classified as <6 h/day, 6-8 h/day, or ≥ 8 h/day. Survey-weighted Cox proportional hazards models examined the independent and joint associations of physical activity and sitting time with all-cause, cardiovascular disease, cancer and other-cause mortality.
RESULTS: During a median follow-up of 78 months, 673 (13.8%) deaths occurred, including 201 from cardiovascular disease, 162 from cancer, and 310 from other causes. Both sufficient leisure-time physical activity and shorter sitting time were independently associated with lower risks of all-cause, cardiovascular disease, and other-cause mortality, but not cancer mortality. In joint analyses, participants with sufficient physical activity and < 6 h/day sitting had the lowest all-cause (adjusted hazard ratio 0.25, 95% confidence interval 0.16-0.39), cardiovascular disease (adjusted hazard ratio 0.15, 95% confidence interval 0.08-0.30) and other-cause (adjusted hazard ratio 0.17, 95% confidence interval 0.08-0.37) mortality, compared with those with insufficient physical activity and ≥ 8 h/day sitting.
CONCLUSION: In this prospective cohort study of US postmenopausal women, the combination of sufficient physical activity and lower sitting time was associated with lower risks of all-cause and cardiovascular disease mortality.
METHODS: We analyzed 5355 postmenopausal women (median age 63 years [interquartile range 56-71]) from the National Health and Nutrition Examination Survey (NHANES) 2007-2018. Leisure-time physical activity was categorized as insufficient (<600 metabolic equivalent of task minutes per week) or sufficient (≥600 metabolic equivalent of task minutes per week). Sitting time was classified as <6 h/day, 6-8 h/day, or ≥ 8 h/day. Survey-weighted Cox proportional hazards models examined the independent and joint associations of physical activity and sitting time with all-cause, cardiovascular disease, cancer and other-cause mortality.
RESULTS: During a median follow-up of 78 months, 673 (13.8%) deaths occurred, including 201 from cardiovascular disease, 162 from cancer, and 310 from other causes. Both sufficient leisure-time physical activity and shorter sitting time were independently associated with lower risks of all-cause, cardiovascular disease, and other-cause mortality, but not cancer mortality. In joint analyses, participants with sufficient physical activity and < 6 h/day sitting had the lowest all-cause (adjusted hazard ratio 0.25, 95% confidence interval 0.16-0.39), cardiovascular disease (adjusted hazard ratio 0.15, 95% confidence interval 0.08-0.30) and other-cause (adjusted hazard ratio 0.17, 95% confidence interval 0.08-0.37) mortality, compared with those with insufficient physical activity and ≥ 8 h/day sitting.
CONCLUSION: In this prospective cohort study of US postmenopausal women, the combination of sufficient physical activity and lower sitting time was associated with lower risks of all-cause and cardiovascular disease mortality.