Oncotarget · 2021
Optimization of tumor spheroid model in mesothelioma and lung cancers and anti-cancer drug testing in H2052/484 spheroids.
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Silvestrini L-G, Santos M-F, Rodrigues B-D, Gonzaga L-M, Martelli-Júnior H, Fabri G-M, Maia-Lima M-P, Ferreira L-M
Аннотация
BACKGROUND: A bidirectional relationship between periodontal disease (PD) and rheumatoid arthritis (RA) has been widely investigated, highlighting the potential impact of oral diseases on systemic health. This bibliometric and altmetric analysis aimed to evaluate the 100 most-cited articles exploring the association between PD and RA.
MATERIALS AND METHODS: A bibliometric review was conducted in accordance with the BIBLIO guidelines. The Scopus database was searched to identify the 100 most-cited articles, and citation counts were cross-validated in the Web of Science database. Data collected included publication year, citation counts, journals, authors, institutions, countries, study design, and collaboration patterns. Bibliometric networks were visualized using VOSviewer, altmetric data were obtained from the Dimensions platform, and public interest trends were analyzed using Google Trends.
RESULTS: The selected articles accumulated 14,753 citations (mean: 147.5 citations per article). Scientific output increased in the 1990s, peaked between 2005 and 2015, and declined thereafter. Research production was concentrated in high-income countries, particularly the United States, the United Kingdom, and Australia, and the resulting articles were published in high-impact journals. The literature primarily focused on molecular mechanisms and biomarkers, whereas clinical trials were comparatively scarce. Altmetric scores demonstrated a weak but statistically significant (p=0.001) positive correlation with citation counts.
CONCLUSIONS: This is a well-established, interdisciplinary research field whose academic influence and public relevance are well documented. Nevertheless, limited geographic diversity and a relative paucity of interventional studies remain. Future multicenter and translational investigations are warranted to address these gaps and further advance clinical understanding.
MATERIALS AND METHODS: A bibliometric review was conducted in accordance with the BIBLIO guidelines. The Scopus database was searched to identify the 100 most-cited articles, and citation counts were cross-validated in the Web of Science database. Data collected included publication year, citation counts, journals, authors, institutions, countries, study design, and collaboration patterns. Bibliometric networks were visualized using VOSviewer, altmetric data were obtained from the Dimensions platform, and public interest trends were analyzed using Google Trends.
RESULTS: The selected articles accumulated 14,753 citations (mean: 147.5 citations per article). Scientific output increased in the 1990s, peaked between 2005 and 2015, and declined thereafter. Research production was concentrated in high-income countries, particularly the United States, the United Kingdom, and Australia, and the resulting articles were published in high-impact journals. The literature primarily focused on molecular mechanisms and biomarkers, whereas clinical trials were comparatively scarce. Altmetric scores demonstrated a weak but statistically significant (p=0.001) positive correlation with citation counts.
CONCLUSIONS: This is a well-established, interdisciplinary research field whose academic influence and public relevance are well documented. Nevertheless, limited geographic diversity and a relative paucity of interventional studies remain. Future multicenter and translational investigations are warranted to address these gaps and further advance clinical understanding.