Aging clinical and experimental research · 2026
Association of dynapenic abdominal obesity with prevalence and incidence of symptomatic knee osteoarthritis among the middle-aged and older Chinese.
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Wu Weipeng, Fu Chenfeng, Zhao Yu, Zhao Jijun
Аннотация
BACKGROUND: Dynapenic abdominal obesity contributes to multiple detrimental health consequences, but its association with symptomatic knee osteoarthritis (KOA) remains undefined. This research sought to determine its cross-sectional and longitudinal relationships with the prevalence and incidence of KOA in middle-aged and elderly Chinese.
METHODS: Cross-sectional analysis comprised 12,872 participants from the 2011 China Health and Retirement Longitudinal Study (CHARLS). The longitudinal analysis utilized a cohort of 11,098 participants without KOA in 2011 as the baseline cohort, with subsequent follow-up conducted until 2018. On the basis of the presence of dynapenia (handgrip strength < 26 kg for men, < 16 kg for women) and abdominal obesity (waist circumference ≥ 90 cm for men, ≥ 85 cm for women), participants were categorized into four distinct groups. To examine cross-sectional and longitudinal associations, we employed Logistic regression models and Cox proportional hazards models, respectively.
RESULTS: In the fully adjusted cross-sectional analysis, all three dynapenic abdominal obesity groups exhibited significantly elevated odds of symptomatic KOA compared to the ND/NAO reference group: ND/AO (OR = 1.158, 95% CI: 1.031-1.301), D/NAO (OR = 1.957, 95% CI: 1.590-2.408), and D/AO (OR = 1.438, 95% CI: 1.068-1.934). In the longitudinal cohort (n = 11,098), 2,305 new cases of KOA (21.3%) were found during follow-up. In the same way, all three groups were linked to a higher rate of symptomatic KOA: ND/AO (HR = 1.155, 95% CI: 1.059-1.260), D/NAO (HR = 1.434, 95% CI: 1.167-1.761), and D/AO (HR = 1.369, 95% CI: 1.050-1.785).
CONCLUSION: Our findings indicated that dynapenic abdominal obesity emerges as a potentially important risk indicator for symptomatic KOA in the Chinese middle-aged and elderly cohort.
METHODS: Cross-sectional analysis comprised 12,872 participants from the 2011 China Health and Retirement Longitudinal Study (CHARLS). The longitudinal analysis utilized a cohort of 11,098 participants without KOA in 2011 as the baseline cohort, with subsequent follow-up conducted until 2018. On the basis of the presence of dynapenia (handgrip strength < 26 kg for men, < 16 kg for women) and abdominal obesity (waist circumference ≥ 90 cm for men, ≥ 85 cm for women), participants were categorized into four distinct groups. To examine cross-sectional and longitudinal associations, we employed Logistic regression models and Cox proportional hazards models, respectively.
RESULTS: In the fully adjusted cross-sectional analysis, all three dynapenic abdominal obesity groups exhibited significantly elevated odds of symptomatic KOA compared to the ND/NAO reference group: ND/AO (OR = 1.158, 95% CI: 1.031-1.301), D/NAO (OR = 1.957, 95% CI: 1.590-2.408), and D/AO (OR = 1.438, 95% CI: 1.068-1.934). In the longitudinal cohort (n = 11,098), 2,305 new cases of KOA (21.3%) were found during follow-up. In the same way, all three groups were linked to a higher rate of symptomatic KOA: ND/AO (HR = 1.155, 95% CI: 1.059-1.260), D/NAO (HR = 1.434, 95% CI: 1.167-1.761), and D/AO (HR = 1.369, 95% CI: 1.050-1.785).
CONCLUSION: Our findings indicated that dynapenic abdominal obesity emerges as a potentially important risk indicator for symptomatic KOA in the Chinese middle-aged and elderly cohort.