Medicina clinica · 2026
Increased TLR9 protein level and upregulated serum cytokines IL-10 and IFN1A in systemic lupus erythematous patients.
СтатьяНаблюдательное исследованиеНазвание и аннотация: Перевод в очереди
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Grau García Elena, Leal Rodríguez Samuel, Gómez-Lechón Quirós Luis, Román Ivorra Jose Andrés
Аннотация
OBJECTIVE: To investigate the association between serum TLR7 and TLR9 levels and previous viral infections, disease activity, and proinflammatory cytokine levels in SLE patients.
METHODS: A cross-sectional observational study was conducted in patients with SLE and healthy controls. Data on previous infections, disease activity, and clinical parameters were collected. Serum TLR7, TLR9, interleukin-10 (IL-10), and interferon-α (IFN-α) levels were measured by ELISA.
RESULTS: TLR9 levels were significantly higher in SLE patients than in controls (P<0.001). TLR7 levels did not differ between groups but showed a positive association with age (P<0.001). No associations were found between TLR7 or TLR9 levels and CRP, ESR, anti-dsDNA, ENAs, antiphospholipid antibodies, disease activity, previous infections, or disease duration. Lower TLR7 levels were observed in patients with antiphospholipid syndrome (P=0.001). Elevated TLR9 levels were significantly associated with increased IL-10 and IFN-α (P<0.001). TLR7 was not associated with IFN-α, although a trend toward higher levels was observed with elevated IL-10.
CONCLUSION: TLR9 is elevated in SLE and correlates with IL-10 and IFN-α, while TLR7 increases with age. .
METHODS: A cross-sectional observational study was conducted in patients with SLE and healthy controls. Data on previous infections, disease activity, and clinical parameters were collected. Serum TLR7, TLR9, interleukin-10 (IL-10), and interferon-α (IFN-α) levels were measured by ELISA.
RESULTS: TLR9 levels were significantly higher in SLE patients than in controls (P<0.001). TLR7 levels did not differ between groups but showed a positive association with age (P<0.001). No associations were found between TLR7 or TLR9 levels and CRP, ESR, anti-dsDNA, ENAs, antiphospholipid antibodies, disease activity, previous infections, or disease duration. Lower TLR7 levels were observed in patients with antiphospholipid syndrome (P=0.001). Elevated TLR9 levels were significantly associated with increased IL-10 and IFN-α (P<0.001). TLR7 was not associated with IFN-α, although a trend toward higher levels was observed with elevated IL-10.
CONCLUSION: TLR9 is elevated in SLE and correlates with IL-10 and IFN-α, while TLR7 increases with age. .