Photodiagnosis and photodynamic therapy · 2026
Longitudinal changes in retinal structure and visual function after mild methanol inhalation poisoning.
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
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Zhang Shaochi, Zhang Wen, Zeng Yunkao, Li Chunhua, Liu Juan, Qi Xiaolong, Zhu Jiaxing, Liu Wenzhou, Xu Weigang, Yang Hui, Zhou Wei, Zhuang Wenjuan
Аннотация
PURPOSE: To characterizes the retinal structural and functional changes in patients with mild methanol poisoning.
METHODS: This study enrolled 17 patients (34 eyes) with methanol poisoning. All patients received comprehensive treatment based on disease severity. Participants were classified as Group 1 if either eye exhibited a best-corrected visual acuity (BCVA) worse than 0.1 logMAR at initial presentation. Group 2 contained those with BCVA of 20/25 or better. Ophthalmic evaluations were conducted at initial presentation and at 2 weeks, 1, 2, 3, and 4 months after exposure. The longitudinal changes in macular ganglion cell-inner plexiform layer (GCIPL) thickness, peripapillary retinal nerve fiber layer (RNFL) thickness, cup-to-disc ratio (C/D), visual field index (VFI) and mean deviation (MD) were analyzed.
RESULTS: Group 1 experienced significant BCVA recovery (p < 0.001) while Group 2 maintained consistently normal vision throughout the study (p = 0.234). Group 1 showed marked improvement in VFI and MD (both p < 0.001). Group 2 maintained high baseline VFI with slight but significant improvement (p < 0.001) and modest MD gains (p = 0.001). The VFI in Group 1 remained lower than Group 2 at all visits (all p < 0.01). Structurally, both groups exhibited progressive RNFL and GCIPL thinning (p < 0.001), though more severe in Group 1. Group 1 also showed sharper GCIPL reduction, particularly within the first two weeks.
CONCLUSIONS: Mild methanol poisoning can cause progressive structural and functional damage even in patients with normal vision. This dissociation between functional improvement and structural deterioration underscores the necessity for long-term monitoring and the development of neuroprotective strategies.
METHODS: This study enrolled 17 patients (34 eyes) with methanol poisoning. All patients received comprehensive treatment based on disease severity. Participants were classified as Group 1 if either eye exhibited a best-corrected visual acuity (BCVA) worse than 0.1 logMAR at initial presentation. Group 2 contained those with BCVA of 20/25 or better. Ophthalmic evaluations were conducted at initial presentation and at 2 weeks, 1, 2, 3, and 4 months after exposure. The longitudinal changes in macular ganglion cell-inner plexiform layer (GCIPL) thickness, peripapillary retinal nerve fiber layer (RNFL) thickness, cup-to-disc ratio (C/D), visual field index (VFI) and mean deviation (MD) were analyzed.
RESULTS: Group 1 experienced significant BCVA recovery (p < 0.001) while Group 2 maintained consistently normal vision throughout the study (p = 0.234). Group 1 showed marked improvement in VFI and MD (both p < 0.001). Group 2 maintained high baseline VFI with slight but significant improvement (p < 0.001) and modest MD gains (p = 0.001). The VFI in Group 1 remained lower than Group 2 at all visits (all p < 0.01). Structurally, both groups exhibited progressive RNFL and GCIPL thinning (p < 0.001), though more severe in Group 1. Group 1 also showed sharper GCIPL reduction, particularly within the first two weeks.
CONCLUSIONS: Mild methanol poisoning can cause progressive structural and functional damage even in patients with normal vision. This dissociation between functional improvement and structural deterioration underscores the necessity for long-term monitoring and the development of neuroprotective strategies.