Rheumatology (Oxford, England) · 2026
Association of accelerometer-measured physical activity patterns with cardiovascular diseases and mortality in people with osteoarthritis.
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Fan Tianxiang, Xie Qiyu, Chen Jiawei, Zeng Muhui, Chen Shibo, Yang Hao, Ruan Guangfeng, Yang Qian, Zhang Yujie, Li Ye, Cao Peihua, Bennell Kim L, Fu Siu Ngor, Hunter David J, Ding Changhai, Zhu Zhaohua
Аннотация
OBJECTIVE: To explore the associations between accelerometer-measured physical activity patterns and cardiovascular diseases (CVD), CVD-cause mortality and all-cause mortality in people with osteoarthritis (OA).
METHODS: OA participants from the UK biobank with ≥36 h of accelerometer data, collected over one-week, were analysed. Moderate to vigorous physical activity (MVPA) patterns were classified as: 'weekend warriors' (≥150 min/week, >50% on 1-2 days), active regular (>150 min/week) or inactive (<150 min/week). Mean min per week of light physical activity (LPA) were categorized into quartiles based on the distribution in the analytical sample.
RESULTS: Among 10 210 study participants (mean age 58.1 ± 7.1 years; 64.5% female) followed for a median of 6.9 years, there were 1538 incident cases of CVD, and 358 deaths, including 90 from CVD. Compared with inactive MVPA, both weekend warrior [adjusted hazard ratio, aHR (95% CIs); 0.73 (0.64-0.82)] and active regular MVPA [0.75 (0.65-0.87)] significantly lowered the risks of incident CVD. Notably, only the weekend warrior group showed significant reductions in CVD-cause mortality (0.55, 0.33-0.92), and all-cause mortality [0.75 (0.59-0.96)]. Higher levels of LPA may link to lower CVD, CVD-cause mortality and all-cause mortality risks in a dose-response manner. Subgroup analysis indicated that more prominent associations were found in individuals with a body mass index >30 or those aged over 60.
CONCLUSION: Engaging in a weekend warrior pattern may confer unique survival benefits for OA patients, especially among older adults and those with obesity. LPA may have dose-dependent protective effects for CVD and mortality risk in OA patients.
METHODS: OA participants from the UK biobank with ≥36 h of accelerometer data, collected over one-week, were analysed. Moderate to vigorous physical activity (MVPA) patterns were classified as: 'weekend warriors' (≥150 min/week, >50% on 1-2 days), active regular (>150 min/week) or inactive (<150 min/week). Mean min per week of light physical activity (LPA) were categorized into quartiles based on the distribution in the analytical sample.
RESULTS: Among 10 210 study participants (mean age 58.1 ± 7.1 years; 64.5% female) followed for a median of 6.9 years, there were 1538 incident cases of CVD, and 358 deaths, including 90 from CVD. Compared with inactive MVPA, both weekend warrior [adjusted hazard ratio, aHR (95% CIs); 0.73 (0.64-0.82)] and active regular MVPA [0.75 (0.65-0.87)] significantly lowered the risks of incident CVD. Notably, only the weekend warrior group showed significant reductions in CVD-cause mortality (0.55, 0.33-0.92), and all-cause mortality [0.75 (0.59-0.96)]. Higher levels of LPA may link to lower CVD, CVD-cause mortality and all-cause mortality risks in a dose-response manner. Subgroup analysis indicated that more prominent associations were found in individuals with a body mass index >30 or those aged over 60.
CONCLUSION: Engaging in a weekend warrior pattern may confer unique survival benefits for OA patients, especially among older adults and those with obesity. LPA may have dose-dependent protective effects for CVD and mortality risk in OA patients.