Science (New York, N.Y.) · 2026
An opposing molecular gradient axis underlies primate cortical organization.
СтатьяНазвание и аннотация: Перевод в очереди
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Huang Zhi, Yang Qianqian, Li Shenglong, Zhu Xiaojia, Wang He, Lin Jixuan, Zhan Yafeng, Wu Yan, Wang Zefang, Majka Piotr, Qu Haichao, Atapour Nafiseh, Yang Tao, Lin Youning, Cui Luman, Yao Yong-Gang, Liang Zhifeng, Liu Zhen, Li Chao, Wei Wu, Zhou Yi, Ma Shaojie, Shen Zhiming, Wei Xiaoyu, Xu Xun, Liu Shiping, Li Chengyu, Poo Muming, Liu Longqi, Rosa Marcello G P, Sun Yidi, Hao Shijie, Liu Cirong
Аннотация
The principles organizing cellular diversity and connectivity in primate brains remain elusive. By integrating spatial transcriptomics, magnetic resonance imaging, and retrograde labeling in marmosets, we identified two opposing molecular gradients that undergo postnatal refinement, emanating from allocortices and primary sensory cortices, respectively. These gradients reconcile conflicting hypotheses on cortical expansion and characterize distinct cortical areas. Cortical gradients align with thalamic gene expression and thalamocortical projection patterns. At gradient intersections, the default mode network and frontal pole exhibited similar molecular features in humans and marmosets, despite species-specific differences in functional connectivity. Comparative analysis of gradient-related genes showed that marmoset and human auditory cortices are highly similar but differ from those of macaques, potentially reflecting complex vocalization. Together, these opposing gradients represent a fundamental organizing principle of the primate cortex.