BMC medical imaging · 2026
Photoacoustic imaging of oxygen saturation in the radial arterial wall and perivascular tissue in patients with systemic lupus erythematosus.
СтатьяНазвание и аннотация: Перевод в очереди
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Zhong Xiaofang, Pan Yingying, Liu Lixiong, Zheng Yingqi, Wang Hui, Liu Xiaohua, Lin Xiaoxuan, Peng Guijuan, Yu Miaoru, Sheng Yuanyuan, Xu Jinfeng, Luo Shuyu, Liu Yingying
Аннотация
OBJECTIVES: Systemic lupus erythematosus (SLE) is associated with vasculitis of varying severity. Conventional ultrasonography faces challenges in accurately assessing this condition, whereas the development of photoacoustic (PA) imaging offers a promising approach. This study aims to evaluate the clinical utility of PA imaging in assessing vasculitis changes in patients with SLE.
METHODS: A total of 102 patients diagnosed with SLE were enrolled as the case group and subdivided into two subgroups: the non-active group and the active group, according to the systemic lupus erythematosus disease activity index 2000 (SLEDAI-2000) scoring criteria. 35 healthy volunteers were recruited as the control group. PA was performed to measure the oxygen saturation of the bilateral radial arterial wall and perivascular tissues.
RESULTS: (1) Active SLE patients showed significantly elevated oxygen saturation (SO2) levels of radial artery wall and perivascular tissues compared to nonactive patients and healthy controls (p < 0.05). (2) Correlation analysis showed that the average oxygen saturation of bilateral radial artery wall and perivascular tissues was positively correlated with SLEDAI-2000 (r = 0.571) and negatively correlated with complement 3 (C3), complement 4 (C4), and serum albumin (r=-0.453, -0.493, -0.313, respectively). Univariate and multivariate regression analysis showed that SLEDAI-2000 was independently associated with SO2. (3) The SO2 was associated with disease activity status in SLE patients, with an area under the curve (AUC) of 79.6%.
CONCLUSIONS: Photoacoustic imaging effectively detects the oxygen saturation changes in the radial arterial wall and perivascular tissues in patients with SLE. These findings suggest its potential as a tool for evaluating SLE-related vasculitis.
METHODS: A total of 102 patients diagnosed with SLE were enrolled as the case group and subdivided into two subgroups: the non-active group and the active group, according to the systemic lupus erythematosus disease activity index 2000 (SLEDAI-2000) scoring criteria. 35 healthy volunteers were recruited as the control group. PA was performed to measure the oxygen saturation of the bilateral radial arterial wall and perivascular tissues.
RESULTS: (1) Active SLE patients showed significantly elevated oxygen saturation (SO2) levels of radial artery wall and perivascular tissues compared to nonactive patients and healthy controls (p < 0.05). (2) Correlation analysis showed that the average oxygen saturation of bilateral radial artery wall and perivascular tissues was positively correlated with SLEDAI-2000 (r = 0.571) and negatively correlated with complement 3 (C3), complement 4 (C4), and serum albumin (r=-0.453, -0.493, -0.313, respectively). Univariate and multivariate regression analysis showed that SLEDAI-2000 was independently associated with SO2. (3) The SO2 was associated with disease activity status in SLE patients, with an area under the curve (AUC) of 79.6%.
CONCLUSIONS: Photoacoustic imaging effectively detects the oxygen saturation changes in the radial arterial wall and perivascular tissues in patients with SLE. These findings suggest its potential as a tool for evaluating SLE-related vasculitis.