Frontiers in medicine · 2025
The EULAR-OMERACT joint-level scoring of ultrasound synovitis demonstrates good construct validity when tested at the patient-level in comparison with measures of disease activity and joint damage in patients with rheumatoid arthritis.
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Tan York Kiat, Thumboo Julian
Аннотация
OBJECTIVE: Patient-level ultrasound joint inflammation outcomes, derived from the European Alliance of Associations for Rheumatology-Outcome Measures in Rheumatology (EULAR-OMERACT) joint-level scoring of elementary components and the combined score (CS), were compared with measures of disease activity and joint damage in patients with rheumatoid arthritis (RA).
METHODS: Clinical joint assessment and a 22-joint (bilateral hands/wrists) ultrasonography were performed independently during the same patient study visit. Patient-level ultrasound joint inflammation outcomes [total power Doppler (PD) score, total grayscale (GS) score, total CS, number of joint(s) with CS ≥ 2 (at least moderate synovitis), and number of joint(s) with ultrasound synovitis defined as PD > 0 or GS ≥ 2] derived from the EULAR-OMERACT joint-level scoring system were correlated with Clinical Disease Activity Index (CDAI), 28-joint disease activity score (DAS28), and ultrasound-detected joint damage, i.e., total bone erosion score (TBES). The relationship between the variables was studied using simple linear regression.
RESULTS: A total of 83 RA patients underwent scanning of 1,826 joints in this cross-sectional study. All patient-level ultrasound joint inflammation outcomes showed significant correlations (p < 0.01) with CDAI, DAS28, and TBES (with correlation coefficients ranging from 0.45 to 0.48, 0.38 to 0.45, and 0.66 to 0.83, respectively). A linear regression analysis revealed statistically significant relationships (p < 0.01) for all patient-level ultrasound joint inflammation outcomes in relation to CDAI, DAS28, and TBES (with regression coefficients ranging from 0.603 to 1.260, 0.066 to 0.149, and 0.416 to 0.818, respectively).
CONCLUSION: Patient-level ultrasound joint inflammation outcomes, derived from the EULAR-OMERACT joint-level scoring system, showed good construct validity when compared to both disease activity and joint damage in patients with RA.
METHODS: Clinical joint assessment and a 22-joint (bilateral hands/wrists) ultrasonography were performed independently during the same patient study visit. Patient-level ultrasound joint inflammation outcomes [total power Doppler (PD) score, total grayscale (GS) score, total CS, number of joint(s) with CS ≥ 2 (at least moderate synovitis), and number of joint(s) with ultrasound synovitis defined as PD > 0 or GS ≥ 2] derived from the EULAR-OMERACT joint-level scoring system were correlated with Clinical Disease Activity Index (CDAI), 28-joint disease activity score (DAS28), and ultrasound-detected joint damage, i.e., total bone erosion score (TBES). The relationship between the variables was studied using simple linear regression.
RESULTS: A total of 83 RA patients underwent scanning of 1,826 joints in this cross-sectional study. All patient-level ultrasound joint inflammation outcomes showed significant correlations (p < 0.01) with CDAI, DAS28, and TBES (with correlation coefficients ranging from 0.45 to 0.48, 0.38 to 0.45, and 0.66 to 0.83, respectively). A linear regression analysis revealed statistically significant relationships (p < 0.01) for all patient-level ultrasound joint inflammation outcomes in relation to CDAI, DAS28, and TBES (with regression coefficients ranging from 0.603 to 1.260, 0.066 to 0.149, and 0.416 to 0.818, respectively).
CONCLUSION: Patient-level ultrasound joint inflammation outcomes, derived from the EULAR-OMERACT joint-level scoring system, showed good construct validity when compared to both disease activity and joint damage in patients with RA.