[The role of locally synthesized growth factors and cytokines in pathogenesis of osteoporosis].

Bone remodelling is a complex process involving a number of cellular functions directed toward the coordinated resorption and formation of new bone. Bone remodelling is regulated by systemic hormones and by local factors. The local factors are synthetized by skeletal cells and include growth factors and cytokines. The end product of remodeling is the maintenance of a mineralized bone matrix, and the major organic component is the collagen. Local factors play an important role in pathophysiology of osteoporosis as systemic hormones.