Rheumatology (Oxford, England) · 2025
Nailfold videocapillaroscopy findings correlate with lung outcomes in idiopathic inflammatory myopathies-related interstitial lung disease.
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Sieiro Santos Cristiana, Tandaipan Jose Luis, Castillo Diego, Codes-Mendez Helena, Martínez-Martínez Laura, Magallares Berta, Moya-Alvarado Patricia, Mariscal Anais, Park Hye Sang, Díaz-Torné Cesar, Fernandez-Sanchez Susana P, Bernardez Julia, Corominas Hector, Diez Alvarez Elvira, Castellví Ivan
Аннотация
BACKGROUND: Idiopathic inflammatory myopathies (IIM) are a diverse group of muscle diseases often complicated by interstitial lung disease (ILD), which significantly impacts morbidity and mortality. Krebs von den Lungen-6 (sKL-6) has been proposed as a biomarker for ILD severity. Nailfold videocapillaroscopy (NVC) detects microvascular changes, but its diagnostic and prognostic value in IIM remains unclear.
OBJECTIVE: This study aimed to assess the relationship between NVC abnormalities, sKL-6 levels and pulmonary outcomes in IIM patients.
METHODS: A retrospective analysis was conducted in IIM patients from a reference centre, comparing those with and without ILD. Data included epidemiological, clinical and immunological features, pulmonary function tests, sKL-6 levels and NVC findings. Statistical analyses included Spearman's rank correlation coefficient to assess the relationships between sKL-6 levels, pulmonary function tests and NVC parameters. Multiple logistic regression modelling to identify to identify predictors of IIM-ILD.
RESULTS: Among 95 patients (34% male, median age 55.3 ± 24 years, disease duration 6.8 ± 7 years), ILD was associated with avascular zones (P = 0.004), capillary loss (P = 0.04) and microhaemorrhages (P = 0.04). Negative correlations were observed between capillary loss and enlarged capillaries with forced vital capacity (%FVC) (rs = -0.46, P = 0.001; rs = -0.57, P < 0.0001) and diffusing capacity of the lungs for carbon monoxide (%DLCO) (rs = -0.32, P = 0.04; rs = -0.23, P = 0.03). sKL-6 levels correlated positively with ILD (rs = 0.77, P = 0.0004), microhaemorrhages (rs = 0.21, P = 0.04) and avascular areas (rs = 0.64, P = 0.03), and negatively with %FVC (rs = -0.47, P = 0.001) and %DLCO (rs = -0.59, P = 0.005). Predictors of ILD included male sex, respiratory symptoms, %FVC, %DLCO, sKL-6, anti-Jo1 positivity and NVC abnormalities.
CONCLUSIONS: NVC findings, sKL-6 levels, and autoantibodies are valuable in identifying and monitoring ILD in IIM, highlighting their role in early diagnosis and management.
OBJECTIVE: This study aimed to assess the relationship between NVC abnormalities, sKL-6 levels and pulmonary outcomes in IIM patients.
METHODS: A retrospective analysis was conducted in IIM patients from a reference centre, comparing those with and without ILD. Data included epidemiological, clinical and immunological features, pulmonary function tests, sKL-6 levels and NVC findings. Statistical analyses included Spearman's rank correlation coefficient to assess the relationships between sKL-6 levels, pulmonary function tests and NVC parameters. Multiple logistic regression modelling to identify to identify predictors of IIM-ILD.
RESULTS: Among 95 patients (34% male, median age 55.3 ± 24 years, disease duration 6.8 ± 7 years), ILD was associated with avascular zones (P = 0.004), capillary loss (P = 0.04) and microhaemorrhages (P = 0.04). Negative correlations were observed between capillary loss and enlarged capillaries with forced vital capacity (%FVC) (rs = -0.46, P = 0.001; rs = -0.57, P < 0.0001) and diffusing capacity of the lungs for carbon monoxide (%DLCO) (rs = -0.32, P = 0.04; rs = -0.23, P = 0.03). sKL-6 levels correlated positively with ILD (rs = 0.77, P = 0.0004), microhaemorrhages (rs = 0.21, P = 0.04) and avascular areas (rs = 0.64, P = 0.03), and negatively with %FVC (rs = -0.47, P = 0.001) and %DLCO (rs = -0.59, P = 0.005). Predictors of ILD included male sex, respiratory symptoms, %FVC, %DLCO, sKL-6, anti-Jo1 positivity and NVC abnormalities.
CONCLUSIONS: NVC findings, sKL-6 levels, and autoantibodies are valuable in identifying and monitoring ILD in IIM, highlighting their role in early diagnosis and management.