Physiology & behavior · 2026
CLOCK genotype modulates associations between blue light exposure and circadian activity amplitude.
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Gubin Denis, Kolomeichuk Sergey, Boldyreva Julia, Borisenkov Mikhail, Danilova Lina, Alkhimova Larisa, Cornelissen Germaine, Weinert Dietmar
Аннотация
BACKGROUND: Circadian disruption is linked to adverse health outcomes, but individual susceptibility to light-based timing signals remains unclear. This study assessed how the CLOCK rs1801260 polymorphism modulates the impact of dynamic light exposure and prior SARS-CoV-2 infection on objective physical activity (PA) rhythmicity.
METHODS: 116 adults (75 COVID+) underwent 7-day wrist actigraphy with blue light recording (Tyumen, Russia, 57°N). Cosinor-derived PA parameters (MESOR, amplitude [A], A/M ratio, acrophase) and non-parametric indices assessed rhythmicity. Regression/ANCOVA examined NA_BLE × CLOCK TT vs non-TT × COVID status interactions, controlling for age/sex/BMI.
RESULTS: Poor light hygiene (Normalized Amplitude of Blue Light Exposure, NA BLE < 1) delayed the acrophase and reduced PA amplitude. Specifically, CLOCK rs1801260 TT homozygotes with NA BLE<1 had a reduced absolute (p = 0.032) and normalized (p = 0.003) PA amplitude. CLOCK rs1801260 TT genotype with NA BLE < 1 exhibited reduced PA amplitude compared to C-carriers (β = -0.483, p = 0.017, η² = 0.201) after adjusting for age, sex, and COVID-19 status. A compounding negative effect was noted in TT carriers with both NA BLE < 1 and COVID-19 history, showing an even smaller PA amplitude than C carriers with no history of COVID-19 (p = 0.036).
CONCLUSION: These findings reveal a triple-hit model where genetic susceptibility (CLOCK TT), environmental insult (poor light hygiene), and prior systemic illness (COVID-19) synergistically disrupt circadian activity rhythms. They underscore the need for personalized chronotherapy integrating genetic profiling and post-viral health status.
METHODS: 116 adults (75 COVID+) underwent 7-day wrist actigraphy with blue light recording (Tyumen, Russia, 57°N). Cosinor-derived PA parameters (MESOR, amplitude [A], A/M ratio, acrophase) and non-parametric indices assessed rhythmicity. Regression/ANCOVA examined NA_BLE × CLOCK TT vs non-TT × COVID status interactions, controlling for age/sex/BMI.
RESULTS: Poor light hygiene (Normalized Amplitude of Blue Light Exposure, NA BLE < 1) delayed the acrophase and reduced PA amplitude. Specifically, CLOCK rs1801260 TT homozygotes with NA BLE<1 had a reduced absolute (p = 0.032) and normalized (p = 0.003) PA amplitude. CLOCK rs1801260 TT genotype with NA BLE < 1 exhibited reduced PA amplitude compared to C-carriers (β = -0.483, p = 0.017, η² = 0.201) after adjusting for age, sex, and COVID-19 status. A compounding negative effect was noted in TT carriers with both NA BLE < 1 and COVID-19 history, showing an even smaller PA amplitude than C carriers with no history of COVID-19 (p = 0.036).
CONCLUSION: These findings reveal a triple-hit model where genetic susceptibility (CLOCK TT), environmental insult (poor light hygiene), and prior systemic illness (COVID-19) synergistically disrupt circadian activity rhythms. They underscore the need for personalized chronotherapy integrating genetic profiling and post-viral health status.