European review of aging and physical activity : official journal of the European Group for Research into Elderly and Physical Activity · 2026
Dose-response associations between accelerometer-derived physical activity and sedentary behaviour and hip/knee osteoarthritis: a prospective cohort study.
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Yang Qingqing, Jia Hao, Dou Lin, Zeng Baoqi
Аннотация
OBJECTIVES: To examine the dose-response relationship of accelerometer-derived physical activity and sedentary behaviour with the risk of hip or knee osteoarthritis (OA).
METHODS: We used data from an accelerometer study of the UK Biobank. From 2013 to 2015, 103,660 individuals worn a wrist-worn accelerometer for seven days. Associations between moderate-to-vigorous physical activity (MVPA), total physical activity (TPA), light physical activity (LPA), and sedentary behaviour were investigated using Cox proportional hazard regression models. We examined the dose-response associations using restricted cubic spline models.
RESULTS: Our analyses included 81,436 individuals, with a mean age of 61.58 [SD, 7.85] years and 56.6% of them being female. During a median follow-up of 8.0 years, 2,086 hip OA and 2,729 knee OA occurred. TPA and LPA showed positive linear relationships with incident OA, and sedentary behaviour indicated a negative linear correlation, while MVPA exhibited a nonlinear association. Compared to MVPA of < 75 min/week, the hazard ratios for incident hip OA were 0.81 (95% CI, 0.70-0.93) for 75-149.9 min/week, 0.78 (95% CI, 0.69-0.89) for 150-299.9 min/week, and 0.94 (95% CI, 0.82-1.06) for ≥ 300 min/week. However, no significant association were observed between MVPA and knee OA.
CONCLUSION: A higher level of TPA and LPA is linked to a higher risk of OA, but a moderate level of MVPA is associated with a lower risk of hip OA. Compared to MVPA < 75 min/week, adhering to MVPA of 150-300 min/week reduces hip OA risk by 22% in middle-aged and older adults.
METHODS: We used data from an accelerometer study of the UK Biobank. From 2013 to 2015, 103,660 individuals worn a wrist-worn accelerometer for seven days. Associations between moderate-to-vigorous physical activity (MVPA), total physical activity (TPA), light physical activity (LPA), and sedentary behaviour were investigated using Cox proportional hazard regression models. We examined the dose-response associations using restricted cubic spline models.
RESULTS: Our analyses included 81,436 individuals, with a mean age of 61.58 [SD, 7.85] years and 56.6% of them being female. During a median follow-up of 8.0 years, 2,086 hip OA and 2,729 knee OA occurred. TPA and LPA showed positive linear relationships with incident OA, and sedentary behaviour indicated a negative linear correlation, while MVPA exhibited a nonlinear association. Compared to MVPA of < 75 min/week, the hazard ratios for incident hip OA were 0.81 (95% CI, 0.70-0.93) for 75-149.9 min/week, 0.78 (95% CI, 0.69-0.89) for 150-299.9 min/week, and 0.94 (95% CI, 0.82-1.06) for ≥ 300 min/week. However, no significant association were observed between MVPA and knee OA.
CONCLUSION: A higher level of TPA and LPA is linked to a higher risk of OA, but a moderate level of MVPA is associated with a lower risk of hip OA. Compared to MVPA < 75 min/week, adhering to MVPA of 150-300 min/week reduces hip OA risk by 22% in middle-aged and older adults.