Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova · 2026
[Effect of long-term carbamazepine therapy on bone metabolism in women with epilepsy].
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Rakhimbaeva G S, Muratov F H, Yusupova D Y
Аннотация
OBJECTIVE: To evaluate the impact of long-term carbamazepine monotherapy on bone metabolism and bone mineral density in women with epilepsy.
MATERIAL AND METHODS: The study included 60 women with epilepsy alongside a control group of 55 healthy women. Serum levels of interleukin-7 (IL-7), estradiol, transforming growth factor-beta4 (TGF-β4), alkaline phosphatase, calcium, and phosphorus were measured in all participants. Bone mineral density and structure were assessed using dual-energy X-ray absorptiometry (DEXA).
RESULTS: The findings from the early osteoporosis diagnosis examination revealed that the levels of estradiol, IL-7, and TGF-β4 were outside the normal range. In contrast, calcium, phosphorus, and alkaline phosphatase levels remained within reference ranges. Bone mineral density and T-score measurements obtained via DEXA in the lumbar spine, right radius, and right hip exhibited positive correlations with serum levels of estradiol, IL-7, and TGF-β4. Conversely, significant negative correlations were observed with serum calcium, phosphorus, and alkaline phosphatase.
CONCLUSIONS: Prolonged carbamazepine treatment considerably increases the risk of osteoporosis in women by disrupting hormonal and cytokine regulation, underscoring the critical need to monitor biomarkers such as estradiol, TGF-β4, and IL-7 to facilitate early diagnosis and prevention of osteoporosis.
MATERIAL AND METHODS: The study included 60 women with epilepsy alongside a control group of 55 healthy women. Serum levels of interleukin-7 (IL-7), estradiol, transforming growth factor-beta4 (TGF-β4), alkaline phosphatase, calcium, and phosphorus were measured in all participants. Bone mineral density and structure were assessed using dual-energy X-ray absorptiometry (DEXA).
RESULTS: The findings from the early osteoporosis diagnosis examination revealed that the levels of estradiol, IL-7, and TGF-β4 were outside the normal range. In contrast, calcium, phosphorus, and alkaline phosphatase levels remained within reference ranges. Bone mineral density and T-score measurements obtained via DEXA in the lumbar spine, right radius, and right hip exhibited positive correlations with serum levels of estradiol, IL-7, and TGF-β4. Conversely, significant negative correlations were observed with serum calcium, phosphorus, and alkaline phosphatase.
CONCLUSIONS: Prolonged carbamazepine treatment considerably increases the risk of osteoporosis in women by disrupting hormonal and cytokine regulation, underscoring the critical need to monitor biomarkers such as estradiol, TGF-β4, and IL-7 to facilitate early diagnosis and prevention of osteoporosis.