Archives of physiology and biochemistry · 2025
Prior resistance training exerts cardioprotection against cardiac remodelling after myocardial infarction.
СтатьяНазвание и аннотация: Перевод в очереди
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Silva Flávio André, Portes Leslie Andrews, Antonio Ednei Luiz, Dos Santos Luis Felipe Neves, Oliveira Helenita Antonia, Teixeira Ighor Luiz Azevedo, Dias André Rodrigues Lourenço, Tucci Paulo José Ferreira, Serra Andrey Jorge
Аннотация
Background: The cardioprotective properties of resistance training (RT) in infarcted rats have been poorly investigated. This study aimed to evaluate the effects of eight weeks of RT prior myocardial infarction (MI) in rats. Method: Groups: SSh: sedentary sham surgery; SMI: sedentary MI; TMI: trained MI. At the end of the eighth week, the animals underwent either MI or sham surgery and were analysed four weeks later. Results: The TMI presented MI sizes, scar areas, masses of the atria, right ventricle, heart, left atrial area, E wave, and E/A ratio, smaller than the SMI. The protein expression related to Ca2+ handling were not affected by the RE. The maximal load (ML) of the TMI was greater than that of the SMI group. The VO2 peak and maximum speed (Vmax) were lower in the infarcted groups. Conclusion: Prior RT confers cardioprotection against cardiac remodelling by attenuating infarct size progression, myocardial hypertrophy, and diastolic dysfunction.