Pathology of Common Nonneoplastic Orthopedic Diseases.

The tissues removed in the surgical treatment of nonneoplastic musculoskeletal diseases represent the most frequent source of surgical pathology specimens in bone and soft tissue pathology. The pathologic changes in these specimens are often not appreciated because of the lack of familiarity with the pathophysiology of the disorders, the mechanisms in which they affect tissue, and their morphologic expressions. In this review, we highlight the important diagnostic features of selecting common nonneoplastic diseases of the musculoskeletal system that cause significant disability and morbidity.