Clinical rheumatology · 2026
Determinant of health-related quality of life among patients with rheumatoid arthritis in North West Ethiopia, 2025: a multicenter cross-sectional study.
СтатьяМногоцентровое исследованиеНазвание и аннотация: Перевод в очереди
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Zerihun Tigabu Eskeziya, Bekalu Abaynesh Fentahun, Kasaw Abel Temeche, Mussie Desalegn Addis, Wondm Samuel Agegnew, Mersha Edmealem Minlarg, Tadesse Tesfaye Yimer, Gelaye Abebech Tewabe
Аннотация
OBJECTIVE: This study aimed to assess determinants of health-related quality of life among patients with rheumatoid arthritis in northwest Ethiopia in 2025.
METHOD: A multi-center cross-sectional design was employed. A systematic random sampling technique was utilized to collect data. Face-to-face interviews with respondents from selected hospitals were conducted to gather data. The analysis was performed on a sample of 422 rheumatoid arthritis patients randomly selected from a total of 5280 across six comprehensive specialized hospitals in northwestern Ethiopia. Multiple linear regression was used to identify associated factors. Statistical significance was set at P-value < 0.05.
RESULT: The summaries of the physical and mental components had mean scores of 30.7 (SD, 11.35) and 43.5 (SD, 12.01), respectively. The physical component summary was negatively associated with being uneducated (β = - 0.14, 95% CI (-4.03,-0.04)), high disease activity (β =-0.63, 95% CI (-20.70,-11.95)), and unavailability of medication (β = - 0.24, 95% CI (-5.23,-1.45)). Being employed was positively associated (β = 0.12, 95% CI (0.08, 4.81)). The mental component summary was negatively associated with obesity (β = -0.18, 95% CI (-9.62,-0.45)), high disease activity (β = -0.55, 95% CI (-20.45,-9.95)), marital status (β =-0.21, 95% CI (-5.79, -1.12)), and unavailability of medication (β = -0.12, 95% CI (-6.31,-1.54)).
CONCLUSION: Overall, the study revealed that health-related quality of life was poor. Rheumatoid arthritis patients' physical health-related quality of life was more affected than their mental quality of life. Factors such as being single, disease activity, medication availability, and disease duration influence health-related quality of life. Prioritizing therapeutic education and medication availability for patients with long-standing disease and high disease activity is crucial to improving health-related quality of life. Key Points • Poor health-related quality of life: Patients with rheumatoid arthritis (RA) in North West Ethiopia experience significantly low health-related quality of life, particularly in physical health. • Determinants identified: Key factors affecting quality of life include marital status, disease activity, obesity, medication availability, and duration of illness, with single and obese patients particularly affected. • Need for education and access: Emphasizing therapeutic education and ensuring medication availability for patients with prolonged disease duration and high disease activity is vital for improving health outcomes. • Healthcare recommendations: Targeted public health interventions should address socio-demographic influences and enhance health literacy among RA patients to improve their quality of life.
METHOD: A multi-center cross-sectional design was employed. A systematic random sampling technique was utilized to collect data. Face-to-face interviews with respondents from selected hospitals were conducted to gather data. The analysis was performed on a sample of 422 rheumatoid arthritis patients randomly selected from a total of 5280 across six comprehensive specialized hospitals in northwestern Ethiopia. Multiple linear regression was used to identify associated factors. Statistical significance was set at P-value < 0.05.
RESULT: The summaries of the physical and mental components had mean scores of 30.7 (SD, 11.35) and 43.5 (SD, 12.01), respectively. The physical component summary was negatively associated with being uneducated (β = - 0.14, 95% CI (-4.03,-0.04)), high disease activity (β =-0.63, 95% CI (-20.70,-11.95)), and unavailability of medication (β = - 0.24, 95% CI (-5.23,-1.45)). Being employed was positively associated (β = 0.12, 95% CI (0.08, 4.81)). The mental component summary was negatively associated with obesity (β = -0.18, 95% CI (-9.62,-0.45)), high disease activity (β = -0.55, 95% CI (-20.45,-9.95)), marital status (β =-0.21, 95% CI (-5.79, -1.12)), and unavailability of medication (β = -0.12, 95% CI (-6.31,-1.54)).
CONCLUSION: Overall, the study revealed that health-related quality of life was poor. Rheumatoid arthritis patients' physical health-related quality of life was more affected than their mental quality of life. Factors such as being single, disease activity, medication availability, and disease duration influence health-related quality of life. Prioritizing therapeutic education and medication availability for patients with long-standing disease and high disease activity is crucial to improving health-related quality of life. Key Points • Poor health-related quality of life: Patients with rheumatoid arthritis (RA) in North West Ethiopia experience significantly low health-related quality of life, particularly in physical health. • Determinants identified: Key factors affecting quality of life include marital status, disease activity, obesity, medication availability, and duration of illness, with single and obese patients particularly affected. • Need for education and access: Emphasizing therapeutic education and ensuring medication availability for patients with prolonged disease duration and high disease activity is vital for improving health outcomes. • Healthcare recommendations: Targeted public health interventions should address socio-demographic influences and enhance health literacy among RA patients to improve their quality of life.