Tropical medicine & international health : TM & IH · 2008
Detection and modelling of case clusters for urban leptospirosis.
СтатьяПоддержка NIH: внешняя программаПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Tassinari Wagner S, Pellegrini Debora C P, Sá Claudio B P, Reis Renato B, Ko Albert I, Carvalho Marilia S
Аннотация
OBJECTIVE: To analyse the epidemiological profile of 488 cases of leptospirosis in Rio de Janeiro, Brazil between 1997 and 2002, using a variety of methods of spatial epidemiology, to establish alert guidelines in general hospitals, which might be a tool to improve diagnosis and treatment of leptospirosis to reduce lethality rates.
METHODS: Scan statistics identified six space-time clusters, which comprised a range of 2 to 28 cases per cluster. Generalized linear mixed models were used to evaluate risk factors for a cluster case which incorporated individual characteristics and spatial information on environmental and climactic factors in a single model frame.
RESULTS: Cluster case events were associated with heavy rainfall (OR 3.71; 95% CI 1.83-7.51). The model did not identify socioeconomic or environmental covariates that significantly influence the risk of developing a cluster rather than non-cluster case.
CONCLUSION: Clustering of leptospirosis in this urban setting appears to be due to transmission during heavy rainfall.
METHODS: Scan statistics identified six space-time clusters, which comprised a range of 2 to 28 cases per cluster. Generalized linear mixed models were used to evaluate risk factors for a cluster case which incorporated individual characteristics and spatial information on environmental and climactic factors in a single model frame.
RESULTS: Cluster case events were associated with heavy rainfall (OR 3.71; 95% CI 1.83-7.51). The model did not identify socioeconomic or environmental covariates that significantly influence the risk of developing a cluster rather than non-cluster case.
CONCLUSION: Clustering of leptospirosis in this urban setting appears to be due to transmission during heavy rainfall.