American journal of physical medicine & rehabilitation · 2024
Effect of the ACTN3 R577X Polymorphism on Serum Creatine Kinase and Interleukin-6 Levels After Maximal Eccentric Exercise.
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Deguchi Minoru, Homma Hiroki, de Almeida Kathleen Y, Kozuma Ayumu, Saito Mika, Tsuchiya Yosuke, Kouzaki Karina, Ochi Eisuke, Okamoto Takanobu, Nakazato Koichi, Kikuchi Naoki
Аннотация
OBJECTIVE: This study explored the interaction among ACTN3 R577X polymorphism, muscle damage, and postexercise inflammatory response by assessing changes over time in serum creatine kinase and interleukin-6 levels.
DESIGN: Ninety-five active Japanese participants (50 men and 45 women: 22.2 ± 2.3 yrs) who did not perform daily upper limb strength exercises were enrolled. Participants executed five sets of six maximal eccentric elbow flexion exercises. The exercise duration was 9 mins, including rest between sets (90 secs). Maximum voluntary isometric contraction, range of motion, muscle soreness, and serum creatine kinase and interleukin-6 levels were assessed pre and post and 1, 2, 3, and 5 days after exercise. Genotype groups were classified as RR + RX and XX based on the absence of ACTN3 expression.
RESULTS: A significant time and group interaction ( P = 0.045) on creatine kinase levels was observed between the groups, indicating that the absence of ACTN3 significantly affects creatine kinase changes. Conversely, no significant interaction on change in interleukin-6, maximum voluntary isometric contraction, range of motion, and muscle soreness was observed between groups.
CONCLUSIONS: The results highlight an interaction on creatine kinase activity after exercise by ACTN3 R577X polymorphism, with elevated activity in the XX genotype.
DESIGN: Ninety-five active Japanese participants (50 men and 45 women: 22.2 ± 2.3 yrs) who did not perform daily upper limb strength exercises were enrolled. Participants executed five sets of six maximal eccentric elbow flexion exercises. The exercise duration was 9 mins, including rest between sets (90 secs). Maximum voluntary isometric contraction, range of motion, muscle soreness, and serum creatine kinase and interleukin-6 levels were assessed pre and post and 1, 2, 3, and 5 days after exercise. Genotype groups were classified as RR + RX and XX based on the absence of ACTN3 expression.
RESULTS: A significant time and group interaction ( P = 0.045) on creatine kinase levels was observed between the groups, indicating that the absence of ACTN3 significantly affects creatine kinase changes. Conversely, no significant interaction on change in interleukin-6, maximum voluntary isometric contraction, range of motion, and muscle soreness was observed between groups.
CONCLUSIONS: The results highlight an interaction on creatine kinase activity after exercise by ACTN3 R577X polymorphism, with elevated activity in the XX genotype.