Communications medicine · 2024
Mediterranean diet and associations with the gut microbiota and pediatric-onset multiple sclerosis using trivariate analysis.
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Mirza Ali I, Zhu Feng, Knox Natalie, Black Lucinda J, Daly Alison, Bonner Christine, Van Domselaar Gary, Bernstein Charles N, Marrie Ruth Ann, Hart Janace, Yeh E Ann, Bar-Or Amit, O'Mahony Julia, Zhao Yinshan, Hsiao William, Banwell Brenda, Waubant Emmanuelle, Tremlett Helen
Аннотация
BACKGROUND: The interplay between diet and the gut microbiota in multiple sclerosis (MS) is poorly understood. We aimed to assess the interrelationship between diet, the gut microbiota, and MS.
METHODS: We conducted a case-control study including 95 participants (44 pediatric-onset MS cases, 51 unaffected controls) enrolled from the Canadian Pediatric Demyelinating Disease Network study. All had completed a food frequency questionnaire ≤21-years of age, and 59 also provided a stool sample.
RESULTS: Here we show that a 1-point increase in a Mediterranean diet score is associated with 37% reduced MS odds (95%CI: 10%-53%). Higher fiber and iron intakes are also associated with reduced MS odds. Diet, not MS, explains inter-individual gut microbiota variation. Several gut microbes abundances are associated with both the Mediterranean diet score and having MS, and these microbes are potential mediators of the protective associations of a healthier diet.
CONCLUSIONS: Our findings suggest that the potential interaction between diet and the gut microbiota is relevant in MS.
METHODS: We conducted a case-control study including 95 participants (44 pediatric-onset MS cases, 51 unaffected controls) enrolled from the Canadian Pediatric Demyelinating Disease Network study. All had completed a food frequency questionnaire ≤21-years of age, and 59 also provided a stool sample.
RESULTS: Here we show that a 1-point increase in a Mediterranean diet score is associated with 37% reduced MS odds (95%CI: 10%-53%). Higher fiber and iron intakes are also associated with reduced MS odds. Diet, not MS, explains inter-individual gut microbiota variation. Several gut microbes abundances are associated with both the Mediterranean diet score and having MS, and these microbes are potential mediators of the protective associations of a healthier diet.
CONCLUSIONS: Our findings suggest that the potential interaction between diet and the gut microbiota is relevant in MS.