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DOI 10.21037/atm-22-3570

Медицинская библиотека · Annals of translational medicine · 2022

Stroke incidence and cognitive outcomes of intracranial atherosclerotic stenosis: study protocol for a multicenter, prospective, observational cohort study.

Si Qianqian, Teng Yuming, Liu Caiyan, Yuan Weizhuang, Fan Xiaoyuan, Zhang Xiaoqian, Zhang Zongmuyu, Li Mingli, Liu Qing, Wang Peng, Yan Zhongrui, Wu Bo, Liu Qiang, Li Hangjuan, Ji Yan, Ran Yuncai, Song Bo, Zhu Shiguang, Li Hongyan, Guan Jingxia, Zhao Manli, Hao Yonggang, Wang Pengfei, Bian Hong, Wang Ningfen, Wang Yulin, Pan Yuning, An Hongwei, Guo Rong, Han Cong, Zhang Junshi, Wang Hebo, You Yong, Jiang Hongquan, Liu Zifan, Liu Jingli, Tao Dingbo, Piao Xiangyu, Zhang Jiangtao, Wang Pei, Yang Shen, Liu Zhou, Wei Xiue, Han Kai, Shi Zhimin, Liu Aihua, Zhang Zuowen, Ma Chunye, Wang Baichen, Zhang Gejuan, Song Chengguang, Zhang Guilian, Yang Xiao, Chen Bing, Lu Baoquan, Chen Beilei, Zuo Meng, Han Kun, Zhang Xiaodan, Cao Wenfeng, Wu Lingfeng, Li Qi, Geng Xiaokun, Zhou Junshan, Zhong Mengfei, Wang Minghua, Chen Yangmei, Liu Jiachun, Wang Tingrui, Deng Youqing, Xu Weihai

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Аннотация

BACKGROUND

Intracranial atherosclerotic stenosis (ICAS) is one of the leading causes of stroke worldwide. Current diagnostic evaluations and treatments remain insufficient to assess the vulnerability of intracranial plaques and reduce the recurrence of stroke in symptomatic ICAS. On the other hand, asymptomatic ICAS is associated with an increased risk of cognitive impairment. The pathogenesis of ICAS related cognitive decline is largely unknown. The aim of SICO-ICAS study (stroke incidence and cognitive outcomes of ICAS) is to elucidate the pathophysiology of stroke and cognitive impairment in ICAS population, comprehensively evaluating the complex interactions among life-course exposure, genomic variation, vascular risk factors, cerebrovascular burden and coexisting neurodegeneration.

METHODS

SICO-ICAS is a multicenter, prospective, observational cohort study. We aim to recruit 3,000 patients with symptomatic or asymptomatic ICAS (>50% or occlusion) who will be followed up for ≥12 months. All participants will undergo pre-designed magnetic resonance imaging packages, blood biomarkers testing, as well as detailed cognitive domains assessment. All participants will undergo clinical visits every 6 months and telephone interviews every 3 months. The primary outcome measurement is ischemic stroke or cognitive impairment within 12 months after enrollment.

DISCUSSION: This study will establish a large prospective ICAS cohort, hopefully discover new biomarkers associated with vulnerable intracranial plaques, identify subjects at high risk for incident ischemic stroke or cognitive impairment, and eventually propose a precise diagnostic and treatment strategy for ICAS population.

TRIAL REGISTRATION: Chinese Clinical Trials Register ChiCTR2200061938.

Для цитирования: Si Qianqian, Teng Yuming, Liu Caiyan, Yuan Weizhuang, Fan Xiaoyuan, Zhang Xiaoqian, Zhang Zongmuyu, Li Mingli, Liu Qing, Wang Peng, Yan Zhongrui, Wu Bo, Liu Qiang, Li Hangjuan, Ji Yan, Ran Yuncai, Song Bo, Zhu Shiguang, Li Hongyan, Guan Jingxia, Zhao Manli, Hao Yonggang, Wang Pengfei, Bian Hong, Wang Ningfen, Wang Yulin, Pan Yuning, An Hongwei, Guo Rong, Han Cong, Zhang Junshi, Wang Hebo, You Yong, Jiang Hongquan, Liu Zifan, Liu Jingli, Tao Dingbo, Piao Xiangyu, Zhang Jiangtao, Wang Pei, Yang Shen, Liu Zhou, Wei Xiue, Han Kai, Shi Zhimin, Liu Aihua, Zhang Zuowen, Ma Chunye, Wang Baichen, Zhang Gejuan, Song Chengguang, Zhang Guilian, Yang Xiao, Chen Bing, Lu Baoquan, Chen Beilei, Zuo Meng, Han Kun, Zhang Xiaodan, Cao Wenfeng, Wu Lingfeng, Li Qi, Geng Xiaokun, Zhou Junshan, Zhong Mengfei, Wang Minghua, Chen Yangmei, Liu Jiachun, Wang Tingrui, Deng Youqing, Xu Weihai. Stroke incidence and cognitive outcomes of intracranial atherosclerotic stenosis: study protocol for a multicenter, prospective, observational cohort study.. Annals of translational medicine. 2022. DOI: 10.21037/atm-22-3570.

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