Frontiers in cellular and infection microbiology · 2026
Emergence of a carbapenem-resistant Klebsiella pneumoniae ST15-KL19 clone with elevated virulence potential in a tertiary hospital in China.
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Li Guiling, Zhang Yujing, Ren Guqi, Tian Longlong, Jiao Xinan, Sun Lin, Ren Chuanli
Аннотация
INTRODUCTION: Carbapenem-resistant Klebsiella pneumoniae (CRKP) has become a significant global health concern. The convergence of carbapenem resistance and elevated virulence potential has led to increasingly difficult-to-treat K. pneumoniae strains. Among these, ST15 is an expanding global high-risk clone, yet variants with elevated virulence potential carrying the KL19 capsular type remain rarely reported.
METHODS: In this study, we characterized the phenotypic and genomic features of a carbapenem-resistant K. pneumoniae ST15-KL19 clone exhibiting elevated virulence potential, isolated from a tertiary hospital in eastern China.
RESULTS: All isolates exhibited extensive drug resistance, including resistance to carbapenems, and carried the bla KPC-2 gene. Whole-genome sequencing revealed a conserved chromosomal virulence-associated profile and hybrid plasmids carrying multiple resistance determinants. The bla KPC-2 gene was located within a stable composite transposon, suggesting efficient mobility and long-term maintenance. Phylogenetic analysis demonstrated that the isolates were closely related to other Chinese ST15-KL19 strains, indicating recent clonal expansion and local dissemination.
DISCUSSION: The identification of this clone highlights the ongoing convergence of multidrug resistance and elevated virulence potential in K. pneumoniae, which poses challenges for infection control and clinical management. These findings emphasize the importance of continuous genomic surveillance to monitor the spread of high-risk K. pneumoniae lineages.
METHODS: In this study, we characterized the phenotypic and genomic features of a carbapenem-resistant K. pneumoniae ST15-KL19 clone exhibiting elevated virulence potential, isolated from a tertiary hospital in eastern China.
RESULTS: All isolates exhibited extensive drug resistance, including resistance to carbapenems, and carried the bla KPC-2 gene. Whole-genome sequencing revealed a conserved chromosomal virulence-associated profile and hybrid plasmids carrying multiple resistance determinants. The bla KPC-2 gene was located within a stable composite transposon, suggesting efficient mobility and long-term maintenance. Phylogenetic analysis demonstrated that the isolates were closely related to other Chinese ST15-KL19 strains, indicating recent clonal expansion and local dissemination.
DISCUSSION: The identification of this clone highlights the ongoing convergence of multidrug resistance and elevated virulence potential in K. pneumoniae, which poses challenges for infection control and clinical management. These findings emphasize the importance of continuous genomic surveillance to monitor the spread of high-risk K. pneumoniae lineages.