Fluorescein angiography and visual acuity in active uveitis with Behçet disease.

PURPOSE: To determine the association of fluorescein angiography characteristics with visual acuity and visual loss during medical treatment in patients with Behçet uveitis.

METHODS

Ninety-three eyes from 69 Behçet patients with active panuveitis underwent fluorescein angiography, and the characteristic findings by angiography were determined. The patients were followed with immunomodulatory treatment.

RESULTS

Diffuse vascular leakage (73.4%), diffuse macular leakage (66.0%), and disc leakage (52.7%) were the predominant angiographic findings on fluorescein angiography. Multivariate logistic regression analysis revealed that a macular window defect and disc neovascularization on fluorescein angiography were associated with poor visual acuity (<or= 20/200) (p < .05). The presence of macular ischemia on fluorescein angiography was significantly associated with the risk of visual loss (<or= 20/200) at 48 months post-treatment (p < .05).

CONCLUSIONS

These results suggest that fluorescein angiography may be helpful for predicting visual prognosis for Behçet patients with panuveitis.