Cross Cultural Validation of Work Productivity and Activity Impairment Questionnaire in Lupus Patients From Latin America.
Обработка статьи · этапы, ошибки и управление
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Nieto Romina E, Hernández Lucia, Quintana Rosana, Fernández-Ávila Diana, Santillan Erika Palacios, Subils Gisela, Otaduy Cintia, Saurit Verónica, Arturi Valeria, Sattler María E, Lucero Luciana González, Grageda Wilfredo Patiño, Pérez Nicolás, Cosatti Micaela, Crespo Espindola María E, Serventi Joaquín Martínez, Oliveira E Silva Montandon Ana Carolina de, Gasparin Andrese Aline, Duarte Angela, Alvino Laissa, Borba Eduardo F, Parente Luciana, Reis Neto Edgard Torres Dos, Herrera Iris Guerra, Massardo Loreto, Martínez Gustavo Aroca, Medina Hellen, Cañas Davila Carlos A, Quintana-Lopez Gerardo, Toro-Gutiérrez Carlos E, Martínez José, Sánchez Briones Reyna E, Cristóbal Mario Pérez, Martin-Nares Eduardo, Juárez-Vicuña Yaneli, De La Torre Ignacio García, Mendoza Carlos Abud, Esquivel-Valerio Jorge A, Langjahr Patricia, Vazquez Marcos A, Cieza Calderón Jorge N, Ugarte-Gil Manuel F, Quiroz Armando Calvo, Álvarez Rodamin, Pizzarossa Carina, Danza Álvaro, Gómez-Puerta José A, Pons-Estel Bernardo A, Pons Estel Guillermo J, Peláez-Ballestas Ingris
Аннотация
METHODS: GLADEL 2.0 is an observational cohort of SLE patients ≥ 18 years old. Clinical data, disease activity (SLEDAI-2 K), damage index (SDI), physician's global assessment (PGA) and patient-reported outcomes (WPAI-Lupus v2.0, LupusQoL), were assessed at baseline and during follow-up. Construct validity was evaluated through Spearman correlations with SLEDAI-2 K, SDI and LupusQoL. Internal consistency was assessed using Cronbach's alpha and responsiveness over 12 months was analyzed using the Wilcoxon signed-rank test. Appropriate statistical tests (p < 0.05) were performed using R software, version 4.4.0.
RESULTS: Among 1083 patients, 684 were evaluated at baseline and at 12 months. Cronbach's alpha values were: absenteeism 0.54; presenteeism 0.64; overall work impairment 0.62; activity impairment 0.62. WPAI-Lupus v2.0 scores correlated with SLEDAI-2 K (p < 0.001) and negatively with LupusQoL domains. Moderate correlations were observed between activity impairment and physical health, pain and planning (r ≈ -0.52 to -0.58). Presenteeism and overall work impairment also showed moderate correlations with physical health and pain domains (r ≈ -0.49 to -0.53). WPAI-Lupus v2.0 was sensitive to change over 12 months (p = 0.001) for all domains except intimate relationship.
CONCLUSIONS: WPAI-Lupus v2.0 demonstrated good validity, internal consistency, and responsiveness. It correlated with disease activity and quality of life, supporting the WPAI-Lupus v2.0 as a valid tool to assess work and activity impairment in Latin American patients with SLE.