Ocular immunology and inflammation · 2008
Azathioprine in the management of autoimmune uveitis.
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Pacheco Patricio A, Taylor Simon R J, Cuchacovich Miguel T, Diaz Gonzalo V
Аннотация
PURPOSE: To evaluate the role of azathioprine as an immunosuppressive for steroid-resistant autoimmune uveitis (AIU).
METHODS: Patients using oral prednisolone for active AIU without clinical response were recruited. A standard protocol of oral prednisolone and azathioprine was used.
RESULTS: Twenty-seven patients participated in the study: 3 with anterior uveitis, 1 pars planitis, 4 idiopatic panuveitis, 8 Vogt-Koyonagi-Harada syndrome, 3 Behcet disease, and 8 choroidoretinopathies. Complete response was observed in 92%. Eleven patients had well-tolerated minor side effects.
CONCLUSION: Azathioprine is safe and effective in controlling steroid-resistant AIU.
METHODS: Patients using oral prednisolone for active AIU without clinical response were recruited. A standard protocol of oral prednisolone and azathioprine was used.
RESULTS: Twenty-seven patients participated in the study: 3 with anterior uveitis, 1 pars planitis, 4 idiopatic panuveitis, 8 Vogt-Koyonagi-Harada syndrome, 3 Behcet disease, and 8 choroidoretinopathies. Complete response was observed in 92%. Eleven patients had well-tolerated minor side effects.
CONCLUSION: Azathioprine is safe and effective in controlling steroid-resistant AIU.